Brand new clinical trial underway for Parkinson's

[gginto]

I live in Toronto so this is exciting! Check this out:

globalnews.ca/news/7431342/...

[jeffreyn]

Thanks for sharing.

My summary:

This is a Phase 1 clinical trial (N=6) that uses MRI-guided focused ultrasound to temporarily open the blood-brain barrier. This will enable an analogue of the glucocerebrosidase enzyme to be non-invasively delivered to the brain. They are testing whether an increase in glucocerebrosidase will reduce the build-up of alpha-synuclein.

Trial Record:

clinicaltrials.gov/ct2/show...

For an overview of glucocerebrosidase (GCase), see the following SoPD blog post from Simon:

scienceofparkinsons.com/202...

[NellieH]

I live in Toronto, too! These are two first-rate hospitals. Fingers crossed for the trial and for this city's great research community.

[Giovi1960]

Thanks for posting this. Looking forward to hearing more about it.

[Parkinsonjisung]

Really interesting approach. If the approach works, then it may be interesting if it can be applied to gdnf and other similar drugs that previously required surgery

[Limpy932]

I live in the GTA also. Always great to hear of new trials for PD.

[Patrickk]

Bydureon, a repurposed Type 2 Diabetes drug is now in third-stage trials in UK for stopping Parkinson’s in its tracks — results expected 2023. Testing — mice, open label, double blind — has been going on for 10 years and it has been positive every time.

scienceofparkinsons.com/201...

According to a very sensitive test, Homeostasis Model Assessment for Insulin Resistance (HOMA-IR), 2/3 of Parkinson’s patients are supposed to be insulin resistant. IR may be treated with Bydureon (Exanatide). Just an angle that might get us one step closer to Bydureon.

scienceofparkinsons.com/201...

cureparkinsons.org.uk/news/...

* * * * * *

I have found some symptom relief (don’t have very bad case) with Tumeric & black pepper (pepper makes it bioavailable) — recommended by a doctor.

* * * * * *

I just got off B6 (100mcg) -- which seems to be about the only dose available. Boy did it make a big difference. I ran into the post below on "Journey With Parkinson's. Had to read it four-five times -- by a biochemist.

[quote] I started taking a supplement that had relatively large amounts of complex B vitamins (specifically the one labeled number two below) had 100% (400 mcg) folate, 1667% (100 mcg) vitamin B12 and 5000% (100 mg) of vitamin B6 (based on daily requirement from our diet). Over a period of several days I started feeling stiffer, weaker as if my medicine had stopped treating my Parkinson’s. I especially noticed it one day while playing golf because I had lost significant yardage on my shots, I was breathing heavily, and I was totally out of sync with my golf swing. Just in general, my entire body was not functioning well.

[quote] Over a period of several days I started feeling stiffer, weaker as if my medicine had stopped treating my Parkinson’s.

[quote] The older literature says taking more than 15 mg of vitamin B6 daily could compromise the effectiveness of carbidopa to protect levodopa from being activated in the tissues.

journeywithparkinsons.com/2...

[jeffreyn in reply to Patrickk]

Regarding GLP-1R agonists (e.g. Exenatide), see also this very recent SoPD blog post from Simon:

scienceofparkinsons.com/202...

[Arlington7]

I, too, live in Toronto and am pleased to see so many others from T.O. in this forum. Much success to the researchers involved!

[Hikoi]

Sorry to be negative but this sounds like very early days of this trial (about 15 years away) which though advertised as exciting and new seems to me to be just a variation of many others around the world.

Stick to fast walking, you might be the first one after JP to reverse your symptoms. Now that would be news.