Testosterone

[mis37]

Hi all,

Has the level of this hormone something to do with PD.?

What kind of supplement would you take.?

Any comments are welcome.

Thanks

Leticia

[MBAnderson]

Would you rephrase the question?

[sharoncrayn in reply to MBAnderson]

Low test levels are a common comorbidity (probably in excess of 50%) of males with PD (non-motor symptoms), fatigue and depression in the age cohort > 65 years old. It is in some ways similar to prostate cancer although in both cases some disagreement exists as to the extent ( in PC it is the reverse , i.e. high test supposedly leads to PC).

In my support groups, it appears to me that test supplementation works more effectively for reducing ED, depression and muscle wasting than for non-motor cognition (brain fog) or motor dysfunction.

L-Dopa and the use of DAs supposedly increase free test levels with a positive result, but probably not too a great extent (vs. direct test supplementation). Which means PD drug therapy probably doesn't play a role in lowering test like PC drugs do (big time).

Baseline LOW test is somewhere around 275-325 ng/ml although for some men it can go down to 200 ng/ml. Women have minor or very low levels of test or should have.

"Bioavailable"test (free and albumin bound) is the important test to measure.

Sharon

[MBAnderson in reply to sharoncrayn]

Sharon,

Yes, we trade some glib remarks with each other, but this is not one.

Once again, good information, but I don't understand what (I said that) you are responding to??

marc

[sharoncrayn in reply to MBAnderson]

Low test levels are not a critical variable in terms of creating or exacerbating PD. If it were, every male on PC drugs would have PD in spades. They don't.

Low test levels are not healthy, but they don't cause PD. A comorbidity along with a host of other factors most of which are of a secondary nature.

Sharon

[Hidden in reply to sharoncrayn]

"Low test levels are not a critical variable in terms of creating or exacerbating PD. If it were, every male on PC drugs would have PD in spades. They don't."

Using this logic, pretty much nothing matters because there's no single thing that has been proven to result in PD for all users (ok, maybe MPTP). Defining "creating or exacerbating" in this way is narrow to the point of there being no point in discussing the "causes" of PD.

Would you say the same about SSRI use? Meth use? Cocaine use?

The overwhelming majority of SSRI, meth and cocaine users don't develop PD either.

[sharoncrayn in reply to Hidden]

"Using this logic, pretty much nothing matters because there's no single thing that has been proven to result in PD for all users."

We have 5 primary factors (in addition to specific gene mutations) that are well known and that can be directly linked to the development and causation as well as the progression of PD either singularly or in concert. Low test levels is NOT one of them.

"Would you say the same about SSRI use? Meth use? Cocaine use?"

SSRI, meth and cocaine abuse are often a secondary comorbidity with PD supposedly due to the complications of DDS. Meth and Cocaine are well known dopamine binders blocking dopamine therefore decreasing dopamine in the synapse. Definitely a negative factor with PD if abused.

"The overwhelming majority of SSRI, meth and cocaine users don't develop PD either. "

I answered this statement in my above comment. It is an incorrect statement without merit.

Mortality data for these drug abusers is "inconsistent" but CVD disease is typical in this group (when these drugs are used singularly or in combination) and thus implies by association a shorter life span for abusers than the PD population in general. You and I have discussed at length the prevalence of PD by age cohort which is an "old age" disease for the most part (>80+%). So it is highly unlikely that drug abuse when started early in life with meth/cocaine and prolonged over years leads to old age. Instead it leads to "premature death".

Die young from drug abuse and you won't have to endure PD,

Sharon

[Gioc in reply to sharoncrayn]

Sharon, Very true unfortunately.

[Mimer in reply to sharoncrayn]

"We have 5 primary factors (in addition to specific gene mutations) that are well known and that can be directly linked to the development and causation as well as the progression of PD either singularly or in concert. "

Interesting. May I ask what the five primary factors are?

What makes them qualify as primary (top 5 or is it the number of factors that meet defined criteria)?

How solid proof is there to back it up?

[MBAnderson in reply to sharoncrayn]

Ms. Crayon,

The 1st time mis37 posed her question, I was not clear what she was asking, so I was asking her for clarification, but thanks for the info.

marc

[WinnieThePoo]

This is the problem with moderation on this forum. PDC's very mature and constructive responses to someone using unnecessary profanity now look as if addressed to the OP and completely bonkers, because moderation, without any explanation ,has just deleted the offending posts

[Hidden in reply to WinnieThePoo]

You'd think they could have [deleted] so it would still make some sense.

[MBAnderson in reply to WinnieThePoo]

Richard or anyone,

I am just now tuning back into this thread and clearly I missed something because there's little about this thread that I understand.

Would you be good enough to explain what has happened (and can you do so) in a way that does not get the whole thread deleted?

Apparently some comments were deleted, but I thought when that happened there was a notice in place of that comment stating that it was deleted. Excuse my ignorance, but what does OP refer to?

Thank you.

Marc

[Farooqji]

Dear PDConscience, don't waste your energies by engaging in aimless discussion with idiots and spoilers

[Lucal]

The diagnosys of PD has lowered my sex drive below 0. It took me 6/12 months in order to get back to almost normal. Hope my italian's friends will not get offended, but we have a motto that goes "Il cazzo non vuole pensieri". I report it as it is becouse, even if it could results offensive is still part of our pop culture. That said , a glass of wine ( another motto goes "bevi per dimenticare") and some nice underwear helps a lot.

[Gioc in reply to Lucal]

direi che è ora di dare un'occhiatina agli effetti indesiderati delle medicine ... giusto per distinguere quello che è tuo e quello che è loro.

Ciao Luca, com'è l'olio di oliva quest'anno li in Toscana?

[Lucal in reply to Gioc]

Ottimo e abbondante. Qualità fantastica

[AaronS]

Hi Leticia

I have not heard of this theory before, having PD has not affected my testosterone production and I have not felt any other issues. I you can boost testosterone thru a supplement called tribulus or even eating black liquorice can affect testosterone levels.

However I would recommend you do your research on the affect of increasing testosterone within the female body,

Just a heads up 😅

Regards Aaron

[Mimer]

I chose to see this as a serious question since it is interesting.

Actually, depletion of testosterone levels for men are common in PD. I have not seen any reports or studies for women (which of course naturally have lower levels than men, but testosterone also has its functions in the female body). In the link to the study below you can find a number of references to other PD - testosterone studies in the reference list.

But it seems like levodopa or dopamine agonist medication increases the level. That is probably the reason that this is not so much up to discussion in e.g. this forum.

clinicalmovementdisorders.b...

For the interested, there is also a study of some unlucky mice, that got parkinsonian symptoms from sudden testosterone depletion. In the study they also discuss the possible link between stress -> testosterone depletion -> more vulnerable to PD.

sciencedaily.com/releases/2...

I think this is something to bring up with your MD or neuro. It is possible to measure the levels in the blood and most medications are prescripted.

[jackedmonston]

Long before I got diagnosed with PD, I started having trouble with temperature control. I was Almost never warm. And if i wasn’t careful, I would go off the cliff. It could take hours to get back.,,

Typically this is a thyroid issue, but my TSA tested normal so doc refused thyroid med. I found another doc who suggested Thyroid meds and that worked. .

Then, five years ago, two years into my diagnosis, I could feel the cold coming on. This time my doc gave me testosterone gel. It worked.

[beehive23]

i have extremely low T. i decidedd with my dr that adding hormone therapy to the myriad of meds im already on was not in my best interest. hang tough.

[WinnieThePoo]

OP is "original post" or original poster

PDC was responding to some sadly erratic posts with a lot of"f" words and precious little sanity in them

[MBAnderson in reply to WinnieThePoo]

Thank you.

[pmmargo]

6 mg/day of Boron will raise Testosterone levels (in men at least). Researchers are worried that testosterone might aggravate COVID-19 so it might be a bad time to mess with your levels.