quercetin: Proteins Required for Brain and Heart Function Activated by Pickled Capers - gastrointestinal, thyroid, pancreas, muscle....
Researchers from the University of California, Irvine (UCI), School of Medicine have discovered that the compound quercetin, commonly consumed when eating capers, regulates proteins required for bodily processes such as thought, muscular contraction, thyroid, pancreas, and gastrointestinal function.
The ubiquitous flavonoid quercetin is an atypical KCNQ potassium channel activator | Communications Biology 2020 pmc.
I shall try this. How many capers?
That’s fascinating. More and more it seems it is important to eat a wide variety of foods. Who knows when a tiny thing like a caper is the highest concentration of an important compound which can have so many benefits.
How many undiscovered useful compounds are lurking in unusual vegetables?
How many undiscovered useful compounds are lurking in unusual vegetables?
Important question.
That's really interesting, thank you. I've been taking a quercetin supplement for a couple of years as it is an effective natural antihistamine and helps with overreactive mast cells. These seem to be connected to nerve pain (slow neurotransmitter breakdown) and oversensitisation (I also have Small Fibre Neuropathy). But, I had seen some indications that quercetin might disrupt thyroid function and also that it possibly reduces COMT enzyme activity potentially leading to higher catechol oestrogen. Oestrogen exacerbates mast cell release and higher histamine and worsens my pain (and I already know I have slow COMT activity). I had doubled my dose for the last couple of months while shielding (in conjunction with zinc, as quercetin is a zinc ionophore) but dropped back down to 500mg when I found that. Any thoughts appreciated! (Re the last and I agree very important point - I eat as wide a range of different vegetable (and some fruit) as possible). I may be wrong but I'm assuming that over-active COMT is more likely to be in issue in Parkinson's and therefore dopamine being metabolised too fast? Best wishes
I take a quercetin supplement for the following reasons.
The flavonoid quercetin identified as significant inhibitor of PARP-1
Important because -- scienceofparkinsons.com/201...
Quercetin Inhibits Inflammasome Activation
Important because -- scienceofparkinsons.com/201...
Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson’s disease 2020
Compounds that prevent a-syn misfolding
Informative article with links re PD and Gut microbiomeGut-brain axis: Review on the association between Parkinson’s disease and plant lectins
Parkinson's Disease: emerging treatment target, the NLRP inflammasome. 
