Simon's post Parkinson's and mosquitoes

[parkie13]

scienceofparkinsons.com/201...

Looks like an interesting topic.

[laglag]

Very interesting! Thanks for posting....

[chartist]

I had no idea that mosquitoes kill more humans than any animal, by a long shot, at over a half million people per year(830,000)!

After reading this article and if I thought I had a mosquito borne brain health issue, it would make me want to try a chronic course of colloidal silver nanoparticles (AGNPs) as AGNPs have shown the ability to cross the blood brain barrier and is a potent broad spectrum antibiotic and antiviral that at the right particle size range and dose is only modestly toxic to normal human cells at levels that are much more toxic to a very wide assortment of pathogens and most pathogens are unable to develop resistance to AGNPs !

Art

[WinnieThePoo in reply to chartist]

Humans kill 580000 people a year, not mosquitos. They kill over 800000 people a year

[chartist in reply to WinnieThePoo]

Well that's so much better! I was wondering why they had the different numbers, now I get it. Mosquitoes are bad news for people. That was 2015, I imagine that number has grown. Deducting the human predators, the mosquitoes are still way out in front of all of those animals species combined! I could use some insect repellent about now.

[kgold]

I did not read article, but I had always heard that lack of certain B vitamins in your body is what attracted the mosquitoes. My husband (pwp) was always getting bitten (way before his diagnosis) when I never was. It turns out B1 is the vitamin you need to help ward off the mosquitoes. Interesting in light of thiamine conversation here.

[park_bear in reply to kgold]

Same here vitamin B1 acts as a mosquito repellent for me.

[Astra7]

Interesting. If this is the cause how can it be cured?

[felixned]

Thank you for posting. I left the following comment on Simon's site:

Simon,

Thank you for discussing this truly fascinating topic. First I would like to ask you a question regarding virus - alpha-synucleins connection: are the alpha-synucleins that appear in response to the virus infection misfolded? Is it possible that certain genetic defects in the infected cells are changing the way alpha-SN are synthesized in the cells resulting in misfolding? Or is it possible perhaps that the virus itself is capable of changing ASN structure? Is misfolded ASN effective in slowing down virus infection? This is something that could easily be researched in vitro. Was this research ever done? Answering these questions could explain how viral infection turns into a chronic disease as well accumulation of misfolded asn in PD. This certainly would be a major development, right?

Second, could you please shed some light on why I see such lack of interest in viral etiology hypothesis of Parkinson disease? Specifically I am talking about work by Dr. Dourmashkin et al you mentioned on several occasions in this forum. Although many find enterovirus theory quite interesting I couldn't find anyone who would be interested in repeating that research or do it in a blind experiment manner. I even suggested that financial support would be provided for working on this issue, still there were no takers. There were some questions raised about some methods used by the authors but they are certainly reputable and experienced group of scientists. So why is it that nobody wants to continue this research? If true this theory would explain why pd is not found in other species, give some insight into gut PD connection, pd vaccine development, diagnostic tests development, etc. The pay back potential is huge so why nobody is working on this? I would appreciate it if you could please explain me what I am missing.

Thank you,

Felix

I am truly interested in his reply.

[parkie13 in reply to felixned]

Please post your reply if and when you get it. Myself I got a strong gut feeling that PD is caused by a virus.

[parkie13 in reply to parkie13]

Did you read plague by Judy mikovits? You can get an ebook. It's really eye-opening.

[felixned]

I didn't get the reply from Simon yet but I left the following reply to Linda who posted her opinion that learning the cause of PD was irrelevant.

Linda,

I cannot agree with you. PD is a progressive disease and the symptoms change and get worse and worse over time. While it is true that many illnesses are treated in spite of the fact that their etiology is unknown it is my firm believe that we have to learn the cause of PD in order to have representative animal model and to be able to come up with the disease modifying treatment or preventive vaccine. I am sure that what we call PD in our 'macro' world has more than one 'micro' world causes. However I found it very interesting that ALL 14 samples of brain tissues from DIFFERENT people who had PD investigated by Dr Dourmashkin ( f1000research.com/articles/... ) all had similar virus like particles in different stages of virus development that stained with the same AB. Only one of 7 samples in control group had some evidence of virus activity and microscopically it appeared to be a different virus. To date there is NOTHING I repeat NOTHING that slows the disease down and C/L treatment is ineffective for many as well as causing numerous bad side effects. The animal models currently in use are simply not representative of PD and only lead to waste of time and money. I might be too harsh but I have some serious doubts that there is genuine desire to eradicate this illness. I am waiting for the result reporting for the next stage of the ASN AB clinical trial ( prothena, etc.- Simon has extensive writings on these) but I would not be a bit surprised if it shows no significant disease modification benefit. In fact if the misfolded ASN has antiviral properties ( see the question I asked in my post above) we might see the disease progressing faster in spite of significant ASN reduction. I hope Simon can find some time to answer my questions and explain me why nobody is looking at the virus theory closely. By the way for those who doubt that PD can be caused by an infectious agent here is an interesting fact of PD trivia: 4 other members of MJ Fox crew contracted Parkinson at the same time as he did ( intmath.com/blog/environmen... ) . What are the odds?

Thank you,

Felix

[parkie13 in reply to felixned]

Agree, agree!

[parkie13 in reply to felixned]

Did you read the " plague" book by Judy Mikovitz?

[felixned]

Not yet but I put it on the list of books to order. Thanks.

[parkie13 in reply to felixned]

You will love it.