Stopping Parkinson's in its tracks.

[Ianfrizell]

Hi all

This is a link to my vlog about a ground-breaking new treatment that is claimed to stop PD in its tracks.

youtu.be/Y4PNcZf55C8(Not working as expected?)

Cheers,

Ian

[Kia17]

Thank you Ian for sharing.

[MBAnderson]

Thank you Ian.

Jim caster, I think we should get on this.

The claim is it stops PD in its tracks.

Mechanism of action

jem.rupress.org/content/214...

Pharmacology

ncbi.nlm.nih.gov/pubmed/275...

nature.com/articles/s41598-...

Product information sheet.

"... Initiates inflammasomes, complexes in complex diseases including multiple sclerosis, type II diabetes, Alzheimer's, and atherosclerosis..."

caymanchem.com/pdfs/17510.pdf

Safer than Nilotinib

Marc

[jimcaster in reply to MBAnderson]

Thanks for all the research, Marc. Is it actually FDA approved for MS? I couldn't verify that...

[MBAnderson in reply to jimcaster]

You're right. It's being studied for MS.

[MBAnderson in reply to jimcaster]

Well, that was short-lived. Looks like this stuff is out for me. I can't take anything that is extensively metabolized by, an inhibitor or a substrate of CYP3A4, otherwise nilotinib isn't cleared and would accumulate.

C'est la vie.

"Incubation of MCC950 with a panel of cytochrome P450 enzymes showed P450s 2A6, 2C9, 2C18, 2C19, 2J2, and 3A4 catalyze the formation of the major metabolite..."

newdrugapprovals.org/2016/1...

I'm less enthused anyway, because I read something a couple hours ago that says it suppresses the autoimmune system, which I'm not interested in doing

[jimcaster in reply to MBAnderson]

Thanks for all the research, Marc. I'm content to watch from afar for now, but I hope clinical trials proceed quickly. There are so many encouraging possibilities, but the pace of progress is frustratingly slow...

[Erniediaz1018 in reply to MBAnderson]

Thanks for this research

[jimcaster]

Thanks, Ian!

[Erniediaz1018]

I saw some of this guys vlogs before it seems promising but I don't know I think it lacks more research

[WinnieThePoo]

Isn't this the hyped up compound that has at least 2 other threads? Mcc950:Worlds first pill may stop parkinsons". It's like groundhog day.

Promising. Part of the solution maybe, but only starting human trials and so probably 10 years before it reaches market. And if it successfully treats inflammation, that would need to be the sole cause of PD and neuron death. I don't think the researchers claim that.

I take this as another piece in the jigsaw that there is accelerating progress towards defeating PD, and things will get better.

But not the single solution. And not 'stops in its tracks'. This false hope business isn't the fault of the researchers but the headline writers