Oregon Health & Sciences University research project might have found the first treatment to slow or stop progression of Parkinson's disease

[Farooqji]

The Portland institution is one of six places that has quietly tested a new drug that shows the potential to pinpoint the cause of Parkinson's, which has eluded researchers for 200 years.

OHSU now wants people newly diagnosed with Parkinson's who are interested in being part of a clinical trial. Patients must be only two years or less into the disease progression and not taking any medications for related symptoms, such as tremors or balance. At least 30 other places around the country will take part in this second phase

oregonlive.com/health/index...

[sunvox]

That is the best new molecule I have yet to come across. Thanks for sharing. I fired off an email to Prothena asking if they are researching other molecules for other diseases that stem from a mis-folded protein.

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God Speed to these researchers.

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I will be eagerly watching for the trial results!

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Personally if I had PD instead of SCA I would be doing everything in my power to get into this clinical trial:

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clinicaltrials.gov/ct2/show...

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EDIT: A quick search of PRX002 on here, and I see I am late to the party on this discussion as others have been talking about this for some time, including Simon. Anyways, still looks really promising to me. I did find one study where they used passive immunotherapy to treat mice modeled to have SCA1 (the disease I have) and it proved beneficial, but apparently not as dramatic as the results in mice modeled to have PD:

ncbi.nlm.nih.gov/pmc/articl...

[felixned]

I see this is the second post about prx002 from you. The first one from JAMA is of course more interesting. I actually go to neurologist who is one of co-authors of that article. He also runs local clinical trials. I tried to qualify for these trials but I take meds and thus excluded. Two comments about this very effective treatment: 1. There were no significant improvement of symptoms and 2. The jury is still out on whether it is actually slows pd progression.

[Farooqji in reply to felixned]

Phase 2 is limited to low dose treatment and safety is more focused as compared with efficacy. The improvement in symptoms will be better known during Phase 3

[jeffreyn]

This recent article from AlzForum contains some more discussion (and comments) on PRX002.

alzforum.org/news/research-...

[jeffreyn in reply to jeffreyn]

This post on the SoPD blog covers the recently-released PRX002 Phase 1b results (and includes a lot of background information).

scienceofparkinsons.com/201...