Any Parkies suffering with Gout?

[SilentEchoes]

Mayo Clinic is investigating Inosine as a possible therapy to slow the progression of PD. Inosine raises uric acid levels, this is associated with Gout and the side effect is kidney stones . Inosine is neuro-protective; do people with PD also suffer from Gout or vise versa?

Since there are nearly 10,000 registered people in this community, it would be interesting to see how many suffer from gout.

en.wikipedia.org/wiki/Inosine

mayo.edu/research/clinical-...

psychcentral.com/news/2013/...

raysahelian.com/inosine.html

***I'm not endorsing this product.

[Hidden]

i think eliminating dairy can increase your uric acid levels too. i had met a guy at at event in Buffalo this year who had gout, then got PD and his gout went away. and i think that is because PD drops uric acid levels, wheres gout pushes it up and you need a certain level

[alexask in reply to Hidden]

Yes eliminate dairy and especially low fat dairy ( I think cheese is actually ok). I was having porridge with skimmed milk and it did me no good at all. Other things that raise uric acid levels include beer and seafood.

You need to have beer with friends though for the full benefit.

[bassofspades in reply to Hidden]

I dont think gout raises uric acid levels but rather gout is caused by high levels of uric acid that crystalize within the joint spaces, usually the foot

[Hidden in reply to bassofspades]

ah yes that's it - you're right of course!

[park_bear]

The stats for adverse events due to high uric acid levels far outweigh any potential advantage for PD.

[jrg54321 in reply to park_bear]

Maybe, but my uric acid levels were lower than normal. Maybe there is a happy medium Goldilocks level that gives a neuroprotective effect and doesn't cause all the other problems. I have been in the inosine trial for the past year. They have been keeping a close eye on my uric acid levels.

[bassofspades]

I thought i might have gout in my left first metatarsal phylangeal joint (big toe joint) but when i x rayed it, it was just a little arthur itis.

[Mike1942]

You think gout in the foot or toe hurts.? Just wait till you wake one night with it in your knee!!!

[silvestrov]

2 notes:

1) Inosine is not the only supplement which raises uric acid levels. Adenosine triphosphate also raises uric acid levels and both ATP and inosine are athletic supplements:

Adenosine 5′-triphosphate (ATP) supplements are not orally bioavailable: a randomized, placebo-controlled cross-over trial in healthy humans

jissn.biomedcentral.com/art...

2) The uric acid/PD relationship is primarily a male only relationship. The evidence that uric acid has a positive relationship with women is lacking.

Serum uric acid levels in patients with Parkinson's disease: Their relationship to treatment and disease duration

"These associations were significant for men (Rs = −0.441, p = 0.04 and Rs = −0.717, p = 0.03 respectively), but not for women (Rs = −0.221, p = 0.337 and Rs = −0.17, p = 0.966 respectively)."

sciencedirect.com/science/a...

High Uric-Acid Levels, Lower Risk of Parkinson's?

"There was no association between urate levels and Parkinson's disease risk in women, the study found."

webmd.com/parkinsons-diseas...

[windhorsepixy]

My husband - who has PD - had gout on & off as a younger man, but in the past 30 years has passed a number of kidney stones. Not pleasant.

[grower]

Had gout several years ago

[honeycombe3]

Around 10 years ago I had my one & only attack of gout in my left big toe. I have taken Alopurinol ever since as I have no intention of going through the pain again. The ankle & lower leg were so hot you could have fried eggs on them!