Azilect withdrawal?: I'm wondering if... - Cure Parkinson's

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Azilect withdrawal?

rebtar profile image
10 Replies

I'm wondering if anyone has has withdrawal symptoms stopping Azilect. I have early PD, mild left side tremors and minimal rigidity, and was given Azilect to try. After 3weeks I felt very drowsy during the day so with no appreciable difference in symptoms so decided to stop. Cut from 1mg to .5 and last night, the first night of cut, I had horrible RLS in arms and legs, it took me forever to get to sleep. I have had occasional instances of RLS before but rarely like this. Any thoughts?

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rebtar
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10 Replies
M_rosew profile image
M_rosew

It took me a few weeks to adjust to taking Azilect, but then felt better with it. I was encouraged by the possible Neuro protection. I understand coming off would also be difficult and you probably need your Neuro to advise you.

I experienced daytime sleepiness in the early days. Once over the shock of diagnosis I found it was possible to stay awake by keeping busy. I also started doing excercises specific for PD.

rebtar profile image
rebtar in reply toM_rosew

Did the sleepiness eventually go away? I exercise a lot and keep busy but found the sleepiness really uncomfortable.

Hikoi profile image
Hikoi in reply torebtar

Yes i believe sleepiness does get less but could take a while. Can it be taken at night?

Maybe it is more effective than you realise, have you had rls since starting it?

rebtar profile image
rebtar in reply toHikoi

No but I've rarely had RLS in the past -- the last time was a year ago when I had a salmonella infection and was taking antibiotics. I can't really tie this episode to anything but stopping Azilect but I guess I'll see what happens over the next couple of days.

M_rosew profile image
M_rosew in reply torebtar

It didn't exactly 'go away' but I can usually work through it. Occasionally I have a short power-nap in the armchair, setting the alarm for 10 minutes.

Astra7 profile image
Astra7

3 weeks isn't very long to try azilect. I reckon it took 6 months before I had no side effects. Also it is more to slow progression than to treat symptoms, though it helped my fatigue quite quickly.

Magnesium is helpful for restless legs.

donjuan61 profile image
donjuan61

I was told by my neurologist that Azilect does nothing for the symptoms of P D ,but it slows the progression of the disease.

paddyfields profile image
paddyfields in reply todonjuan61

Are you sure thas what he said. Its t he other way round. Azilect helps your body make the most of the available dopamine you have and has n o t been proved to slow t he progression.

laglag profile image
laglag

Azilect helps me with small movements like typing, household chores, cooking. I take 0.5 in the morning & 0.5 around 4:00 & I don't have any side effects. I've been taking it for 13 years. Requip made me extremely sleepy.

Renowife profile image
Renowife

I have been taking Azilect for one year. I recently stopped due to a surgery for two weeks. I did not notice a difference. I did resume taking the drug after the surgery.

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