manitol

[ruthgt]

I have parkinson's fron 2012. Who use manitol? side effects?

[Xenos]

I started mannitol 11 weeks ago. The dosage is what CliniCrowd advised me and I follow it very precisely.

I would love to know if it's better to take it in two half-doses or one, since

- the half-life of mannitol in the body is very short (around 100 min), and

- the concentration is important : not enough and it doesn't work, too much and it doesn't work either.

CliniCrowd do not have the answer to that yet - I wrote them.

The main side effects are bloating and gaz. It's less severe than at the beginning, but still... no social life possible (just kidding).

No other side effect.

[Nivrac77]

Am taking it orally and have had no side effects after 3 months. I worked up from teaspoon to tablespoon daily dose. Thought at first saw some symptom relief but not seeing any significant difference as of today. Best administration is intravenously, not oral, but most US docs won't administer it via IV due to it not being clinically tested. I'm staying on it and am hopeful I may still see benefit.

[ruthgt in reply to Nivrac77]

administraing manitol via iv is for a different purpose.I take tea spoon 2 a day in coffy or tea gives a longer time between meds

[Xenos in reply to ruthgt]

Hi ruthgt,

if you allow me, what you describe must be placebo effect : mannitol shouldn't help on the short term. It is meant to dissolve alpha-synuclein clumps in the brain, that are likely detrimental to dopaminergic neurons.

Experiences in-vitro, then on fruit flies and then on mice showed amazing efficacy.

[ruthgt in reply to Xenos]

XEnos I know that .what are you expecting from manitol .2 tea spoons are o.k. more is a problem

[Xenos in reply to ruthgt]

I'm open minded about the issue but I do have a positive feeling about this whole CliniCrowd experiment. I hope it's followed seriously. They ask me to fill a questionnaire each month. I precisely take my 9 grams per 24 hours. No big deal.

Let's see what happens.

[ruthgt in reply to Xenos]

I am also open minded i used mucuna i use the monitol and i use hemp oil