FEMERA

[many]

MY WIFE IS ON FEMERA POST CHEMOTHERAPY AND IS IT OK TO TAKE POMEGRENATE JUICE WHILE BEING ON FEMERA?

DOES POMEGREANTE NEGATES OR DECREASES THE EFFICACY OF FEMERA?

[sumeet_shah Administrator]

She can very well have pomegranates or any fruit she desires.

No food has any relation to any hormonal treatment at all. There is no restriction. Let her have whatever she wants.

[roxboxfox RadiationOncologist]

Pomegranates and pomegranate extracts have been shown to inhibit breast cancer cell proliferation and invasion and promote cell apoptosis in both estrogen receptor positive (ER+) and negative ER- breast cancer cells in a dose dependent manner, as well as preventing  tumor formation in HER2/neu transgenic mice.

Delphinidin, an anthocyanin found in pomegranates, has been shown to block epidermal growth factor receptor (EGFR) signaling in breast cancer cells. (EGFR, which is expressed at high levels in at least 30% of breast cancers, is associated with a poor prognosis.)

Pomegranate seed oil, fermented pomegranate juice polyphenols, and ellagic acid have all been shown to inhibit angiogenesis (the growth of new blood vessels) in breast cancer cells. Pomegranate fermented juice polyphenols and pomegranate seed oil have also been shown to reduce the number of carcinogen-induced mammary tumors in mice. In addition, pomegranate extract has been shown to inhibit aromatase activity, a process by which androgens are converted to estrogens in the body. 

Pomegranate juice has been shown to inhibit metastatic processes in breast cancer cells. Both pomegranate juice and the combination of luteolin, ellagic acid and punicic acid stimulated the expression of genes that increase breast cancer cell adhesion, as well as inhibiting genes that stimulate cell migration and inhibit breast cancer cells movement to the bone in one study. In addition, the treatments reduced pro-inflammatory compounds, which implies that they could reduce inflammation and its promotion of cancer progression.

CONCLUSION: There is no harm in consuming Pomegranate Juice whilst being on Letrozole.

Regards

Dr Rohit Malde

[sumeet_shah Administrator in reply to roxboxfox]

Wow, Rohit! I didnt know all this. Thanks.