The antimicrobial functions of neutrophils are facilitated by a defensive armamentarium of proteins stored in granules, and by the formation of neutrophil extracellular traps (NETs). However, the toxic nature of these structures poses a threat to highly vascularized tissues, such as the lungs. Here, we identified a cell-intrinsic program that modified the neutrophil proteome in the circulation and caused the progressive loss of granule content and reduction of the NET-forming capacity.
Programmed ‘disarming’ of the neutrop... - Lung Conditions C...
Programmed ‘disarming’ of the neutrophil proteome reduces the magnitude of inflammation.
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2greys
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Right 2grey what does this mean neutrophils seems to be significant but I being stupid dont understand this finding. HELP! Will this help with copd.
Basically it has been discovered that Neutrophils have built in brake to their actions, now they need to find out how to manipulate that braking mechanism. Advances being made now albeit in little steps.
in reply to 2greys
Does this link into other research around G-CSF trying to get to grips now with what I am reading as I was revisiting G-CSF this evening as a research that appears to stem back from the 90s
2greys in reply to
Very much so, very closely related. This still remains our best hope at arresting the progress.
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