These reports show your results for specific genetic variants that are associated with a higher risk for developing certain health conditions. However, these reports cannot tell you whether you definitely will, or will not, develop the condition. Note that there are other genetic variants linked to these conditions that are not covered by these reports. Environmental and lifestyle factors can also contribute to these conditions. If any of these conditions run in your family or you think you might have one of these conditions, consult with a healthcare provider about appropriate testing.
NAMECONFIDENCECONFIDENCE
Alpha-1 Antitrypsin Deficiency
Variant Absent; Typical Risk
Early-Onset Primary Dystonia (DYT1-TOR1A-Related)
Variant Absent; Typical Risk
Factor XI Deficiency
Variant Absent; Typical Risk
Familial Hypercholesterolemia Type B (APOB-Related)
Variant Absent; Typical Risk
Familial Transthyretin (TTR) Amyloidosis
Variant Absent; Typical Risk
Hereditary Breast and Ovarian Cancer Syndrome (BRCA1- and BRCA2-Related, Selected Mutations)
Inherited Thrombophilia (Factor V Leiden- and Prothrombin-Related)
Variant Absent; Typical Risk
Parkinson's Disease (LRRK2- and GBA-Related)
Variant Absent; Typical Risk
Alzheimer's Disease (APOE Variants)
Are they saying there is issues OR why say risk .. take HBOC for example they say I have no Hereditary Breast and Ovarian Cancer Syndrome (BRCA1- and BRCA2-Related, Selected Mutations)
And I do not have any of the three BRCA1/2 mutations reported by 23andMe. But I may still have a different mutation in BRCA1 or BRCA2 (not reported here).
Thanks for typing these out Jeff; I think it means that from the tests you have had, you are not genetically at risk for these conditions. Good news I think. X
I believe these say that you have no greater risk because of your genetics to any of these diseases. The BRCA gene is significant in a genetic disposition to prostate cancer in men and it is believed that testing genetics of someone with prostate cancer for the particular gene can tell whether or not the cancer is aggressive or not despite other tests done which may not show that. I think the trials on this are called "Polaris" A normal genetic test does not test for this to my knowledge but some genetic tests are now being offered by private companies (cost about £1,800 with two consultations one before testing and one after) to show if you have this and therefore would suggest a man who has the gene/mutation to get his PSA tested more regularly and at a younger age and to be more vigilant after what would normally be an insignificant rise and possibly be offered biopsy or scans earlier. Prostate Cancer is curable if caught early but getting tested so that it is caught early is difficult here in the UK. At the moment men get tested annually from age 50 though Docs are not good at telling you this so you have to ask. I know too much about this because my other half's brother gets tested yearly because he has health insurance with his job and they do this and he has told all his male friends and relations who do not know about the testing to get tested. My other brother in law was diagnosed with prostate cancer at 54 - it had already spread by that time and after a lot of treatment died last year at 64. The cancer would have started maybe 10 years before he finally had that first PSA test and both his sisters had ovarian cancer - his elder sister died at 57 from it but his younger sister has survived as it was caught early. Seems the BRCA gene may have had something to do with this and the family are trying to make sure that every one is tested. Thing is his Mum lived to 93 and was as healthy as heck up until about 91 when dementia kicked in but his Dad died at 76 from mesothelioma and emphysema as he had been a miner most of his life.
Sorry for long post PSA testing is a bit of a "hobby horse" for me at the moment. So many men just don't want it done because Doc may do a digital rectal examination (DRE) of the prostate and they really do not want that. Seems they would rather die of ignorance than be slightly embarassed for a short while - A couple of men in our village have said this to us years ago "I'm not going back there" after having one DRE and not going back for further tests both unfortunately died of prostate cancer. Get tested all you men out there!
Thank you Tee. I did take a bit too long to say it though didn't I? What annoys me is that Docs don't even mention this to most men at all and they never get a PSA test until one or other symptom is picked up by which time it may be too late for the easier, less invasive treatments which have fewer life saving side effects. I also annoyed me to read the last findings of the "watch and wait" and treatment trials which said both were as effective over a 10 year period - but more men from the watch and wait category had advanced prostate cancer when going for treatment and watch and wait is no good unless you have good testing and scanning and a GP/consultant who listens - we know how hard they can be to find. On a trial everything would have been done so accurately. Also the PSA score and the agressiveness of the cancer is not always related - many men are found to have aggressive forms of prostate cancer with lower PSA. Am hoping this gene testing will be used - but it is all down to cost!
I didn't think it was too long at all! My father had prostate cancer - though it didn't cause his death - and my husband is 66 and has never had a check. The nagging will begin!! 😊
Thanks for filling in the gaps J. It does seem a bit 'samey' and you do wonder if this is just a stock set of answers. In the plus side, it seems you're not genetically at risk for any diseases but on the minus side, you probably feel you've wasted your money. I hope there's something here that you find helpful.
I always use my phone for HU but thanks for the tip.
Hi Jeff, It reads to me that as the variant is absent for these conditions you have no risk of getting them other than is present in a random fashion in the population at large. As it says, there may be other conditions for which you have not been tested for which you may have the variant. I hope that helps a bit.
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