In Severe COVID, Cytokine “Hurricane” in Lung Attracts Damaging Inflammatory Cells.

[2greys]

A cytokine “hurricane” centered in the lungs drives respiratory symptoms in patients with severe COVID-19, a new study(link is external and opens in a new window) by immunologists at Columbia University Vagelos College of Physicians and Surgeons suggests.

Two cytokines, CCL2 and CCL3, appear critical in luring immune cells, called monocytes, from the bloodstream into the lungs, where the cells launch an overaggressive attempt to clear the virus.

Targeting these specific cytokines with inhibitors may calm the immune reaction and prevent lung tissue damage. Currently, one drug that blocks immune responses to CCL2 is being studied in clinical trials of patients with severe COVID-19.

Survivors of severe COVID-19, the study also found, had a greater abundance of antiviral T cells in their lungs than patients who died, suggesting these T cells may be critical in helping patients control the virus and preventing a runaway immune response.

cuimc.columbia.edu/news/sev...

Immunity. Study Paper,Journal Pre-proof (a PDF File)

cell.com/immunity/pdf/S1074...

[jackdup]

That sounds promising in finding a way to stop the progression of the disease and hopefully to more effective treatments.

[Patk1]

Thanx 4 this

[Patk1 in reply to Patk1]

I'm wondering if ths is why ive not got back to pre covid health.could b interesting if also could be applied to inflammation in our lungs associated with non covid infections