Northwestern University researchers have uncovered a new vulnerability in the novel coronavirus’ infamous spike protein — illuminating a relatively simple, potential treatment pathway.
The spike protein contains the virus’ binding site, which adheres to host cells and enables the virus to enter and infect the body. Using nanometer-level simulations, the researchers discovered a positively charged site (known as the polybasic cleavage site) located 10 nanometers from the actual binding site on the spike protein. The positively charged site allows strong bonding between the virus protein and the negatively charged human-cell receptors.
Leveraging this discovery, the researchers designed a negatively charged molecule to bind to the positively charged cleavage site. Blocking this site inhibits the virus from bonding to the host cell.
Not saying, nothing against you personally. I do not want to prod providence with a sharp stick and another 3 days to go yet before I dare tell of the complication that has occurred.
It has hit 33.5°C presently here, with very little breeze. My reliever has been getting used a lot over the last few days. With a top floor flat, the nights have been at 28°C at midnight even with a fan blowing into the bedroom and windows wide open. Too much, for too long.
To all the global warming deniers, who keep saying where is it? Well here it is, breaking all the heat wave records. Even the summer of '76 was not this hot for so long, even then there was a refreshing Northwesterly air flow. I remember it well being at sea, along with the day that the whole tanker was covered in ladybugs and I mean covered, a real swarm of them, as they took a rest in their flight across the Channel, they were also very hungry and bit you.
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