Preventing spread of SARS coronavirus-2 in humans.

[2greys]

Viruses must enter cells of the human body to cause disease. For this, they attach to suitable cells and inject their genetic information into these cells. Infection biologists from the German Primate Center - Leibniz Institute for Primate Research in Göttingen, together with colleagues at Charité – Universitätsmedizin Berlin, have investigated how the novel coronavirus SARS-CoV-2 penetrates cells. They have identified a cellular enzyme that is essential for viral entry into lung cells: the protease TMPRSS2. A clinically proven drug known to be active against TMPRSS2 was found to block SARS-CoV-2 infection and might constitute a novel treatment option (Cell).

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[PurpleAlf]

This is positive 2greys, thank you. I think we need more positive news right now. Take care x

[Jaybird19]

Cant gt it to download

Just how long does the viral particle remain viable when on skin and when outside the body on metal wood plastic or wool. Does anybody have any idea yet. I saw the figure of 9 hours mentioned but that must have been a guess.

[2greys in reply to Jaybird19]

I have seen all sorts of figures being quoted, right up to 2 days on hard surfaces, not sure about on the skin, though. I would just be cautious and always washing your hands when getting indoors and changing your clothes.

Not forgetting to clean your door handle, on the inside, as well when you come in. You could answer the door to somebody and you then contaminate your hand/s without realising.

[Jaybird19 in reply to 2greys]

Yes and when you come in you unlock door with keys and much later lock it up using same keys. Wash your hands again.

Had new tv recorder delivered today set up for me in unit and connected to various plugs and buttons using remote and demonstrated. I bet those remotes carry all sort of bugs. ...Went shopping and forgot about trolley handles. Then everything i picked off the shelves had been put there by hands and more hands put it tnrough the checkout

It is crazy to even think about it. Must stop !

[2greys in reply to Jaybird19]

Sorry just spotted you could not download it.

Viruses must enter cells of the human body to cause disease. For this, they attach to suitable cells and inject their genetic information into these cells. Infection biologists from the German Primate Center - Leibniz Institute for Primate Research in Göttingen, together with colleagues at Charité – Universitätsmedizin Berlin, have investigated how the novel coronavirus SARS-CoV-2 penetrates cells. They have identified a cellular enzyme that is essential for viral entry into lung cells: the protease TMPRSS2. A clinically proven drug known to be active against TMPRSS2 was found to block SARS-CoV-2 infection and might constitute a novel treatment option (Cell).

Several coronaviruses circulate worldwide and constantly infect humans, which normally caused only mild respiratory disease. Currently, however, we are witnessing a worldwide spread of a new coronavirus with more than 90,000 confirmed cases and over 3,000 deaths. The new virus has been named SARS coronavirus-2 and has been transmitted from animals to humans. It causes a respiratory disease called COVID-19 that may take a severe course. The SARS coronavirus-2 has been spreading since December 2019 and is closely related to the SARS coronavirus that caused the SARS pandemic in 2002/2003. No vaccines or drugs are currently available to combat these viruses.

Stopping virus spread

A team of scientists led by infection biologists from the German Primate Centre and including researchers from Charité, the University of Veterinary Medicine Hannover Foundation, the BG-Unfallklinik Murnau, the LMU Munich, the Robert Koch Institute and the German Center for Infection Research, wanted to find out how the new coronavirus SARS-CoV-2 enters host cells and how this process can be blocked. The researchers identified a cellular protein that is important for the entry of SARS-CoV-2 into lung cells. "Our results show that SARS-CoV-2 requires the protease TMPRSS2, which is present in the human body, to enter cells," says Stefan Pöhlmann, head of the Infection Biology Unit at the German Primate Center. "This protease is a potential target for therapeutic intervention."

Promising drug

Since it is known that the drug camostat mesilate inhibits the protease TMPRSS2, the researchers have investigated whether it can also prevent infection with SARS-CoV-2. "We have tested SARS-CoV-2 isolated from a patient and found that camostat mesilate blocks entry of the virus into lung cells," says Markus Hoffmann, the lead author of the study. Camostat mesilate is a drug approved in Japan for use in pancreatic inflammation. "Our results suggest that camostat mesilate might also protect against COVID-19," says Markus Hoffmann. "This should be investigated in clinical trials."