Reversal agent for Edoxaban

[Peony4575]

I was under the impression that there wasn’t a reversal agent for Edoxaban but there is. Now anyway . The anti coagulation and reversal guidelines from The Walton Centre in Liverpool ( also known as Walton Neuro regional centre of excellence in Liverpool says the following .

“Andexanet Alfa ( Ondexxya) is a recombinant form of human factor Xa which binds specifically to Apixaban, Rivaroxiban and Edoxaban thereby reversing its anti coagulant effects .”

I have made a note in my phone as I don’t trust doctors to know everything and just hope should the need arise that I would be taken to a specialist centre

[AAJJTt]

Hi, interesting , me too. I had previously read about this, while on Edoxaban. However, I didn’t think it covered Edoxaban.

ncbi.nlm.nih.gov/pmc/articl...

Useful to know, I will certainly explore this, should I need to go back on the anticoagulant.

Thanks

[MisterMagoo]

That is interesting, although I wonder how many hospitals will have this routinely available in A&E. I've been pondering stopping taking my Edoxaban in the morning that I go for my bike ride (once or twice a week) until I get back home.

Since my ablation I get Afib once or twice a week for maybe a couple of hours maximum so I think the risk of a clot is minimal in the time frame of being off my Edoxaban.

I would also not stop taking it if, if I had an Afib episode with a couple of days.

[Peony4575 in reply to MisterMagoo]

It costs between £14000 and £25000 per treatment episode and seems to get used only for uncontrollable GI bleeding ( for all the DOACS) I don’t know what they would do if it was a brain bleed . From a recent survey I found it seems over half the acute trusts in England stock it

[Peony4575 in reply to MisterMagoo]

The time I take my Edoxaban varies by a couple of hours anyway, it depends when I get up !

[Ppiman]

I read that other means than reversal are mostly used to deal with any haemorrhaging. Not that I would ever like it to be put to the test! 😟

Steve

[Peony4575 in reply to Ppiman]

Me neither !

[Cally53]

From what I can see, there is still no agent licenced for use in the UK.

[Peony4575 in reply to Cally53]

Never mind the doctors will be able to find it if you are in Edoxaban and have need

[Cally53 in reply to Peony4575]

I'm not on Edoxaban for that very reason.