As I have mentioned before I have persistant AF, I had a cadioversion op, at first it worked, but it then flipped back into persistant AF after ten days. For another medical reason my consultant felt another try with cardioversion op probably wouldn't work so I am now on 10mg Bisoprololol, 180mg Dilitiazem daily and Apixaban twice daily. This has undoubted slowed my heart rate, in the day time its between 75 and 95 beats when resting. The problem I have is when I wake up in morning and before I take meds, it is on average 130. I am a bit worried about this what with the possibly of a stroke. Should I talk to GP about putting up my Dilitazem dose, I think Bisoprolol only goes up to 10mg. If someone has has had drugs to control AF any advise would be appreciated. Or am I worrying about nothing.