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Hi there can anyone help us please. Ever since I started in bisoprolol and was changed to nebivolol 5mg My mood swings are worrying me. Last weekend I had a few beers and I was really bad.

My wife says her laughing joking hubby has disappeared almost overnight into a withdrawn moody anxious person.

Is this the drugs or has anyone else suffered with this at all ?

All comments welcome. Thanks for taking the time to read my post 😀

8 Replies

Bisoprolol made me feel bad, but not depressed, just worn out.I wasn't on it for long though, as it wasn't for me.

But I have had depression brought on by another drug. Took it, after a couple of days went downhill 😩, the whole world became a bad place. Stopped taking it and came straight back up to normal 😀. Tried it for 2nd time just in case it might be something else, but no, down I went 😩.

So drugs can affect your state of mind, no doubt about it in my opinion.

Hope you get to the bottom of it.


1 like

PS. When I told my doc, she changed me to another drug quickly.


Could be, go back to your GP and report it asap, beta blockers are sometimes used to prevent anxiety and any drug that is used to treat a symptom has the capacity to cause it in some people. Anxiety and depression go hand in hand.

Personally I would lay off the beers completely as alcohol is a known antagonist for depression.


I was horrendous when I was on it, like a black cloud had descended, very depressed. I was on 2.5mg twice daily. My GP wasn't very helpful and it was actually my EP that eventually changed my medication.


I went from Bisoprolol to Nebivolol and was then unable to sleep anything longer than 2 hours. It did take the edge off of the Ectopics and Tachycardia but lack of sleep was not an option so I stopped taking them after a month.


Unfortunately I (or rather my wife) have noticed the same effect. Bisoprolol almost killed me as I was asthmatic and the effect of verapamil wear off over time so whilst nebivolol generally keeps my heart healthy it does cause poor sleep and hence irritability.


I have been on 10 mg of bisoprolol for 3years never had a problem


Alcohol and beta blockers don't mix I believe.


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