I had a cryo-ablation on May 7 and stopped taking flecainide five weeks later due to the side effects. One week after that the side effects increased in intensity and although they've tapered off somewhat, they continue - over a month later. I suspect there's still flecainide bound up in my tissues that's being released very slowly. My cardiologist says there's no more in my system because it's hydrophilic, and hydrophilic substances do not bind to proteins.
Having done quite a bit of Internet research on this, I've found at least four facts that make it clear the Dr's logic is faulty. (1: Flecainide is know to have a 40-45% protein binding rate. 2: It's known to have a high volume of distribution. 3. It has a high tissue/plasma ratio, the metric for volume of distribution. 4. Via autopsy, flecainide has been found in human tissue, from 143 mcg/g in lungs to 1.9 in adipose tissue.)
Does anyone have suggestions about how to talk to a medical professional about this?
Later edit: I've recently found a number of studies that refer to flecainide as being lipophilic, and one state poison control center describes it as lipid-soluble. Other studies refer to flec as hydrophilic. Somehow I doubt that there are two different substances being called by the same name.