UChicago Medicine among the first to offer histotripsy for liver tumors . PCa is next.

[Bigmls7890]

uchicagomedicine.org/forefr... cancer is next

[petabyte]

I was wondering how it is different from HIFU. This explains it.

pmc.ncbi.nlm.nih.gov/articl...

High intensity focused ultrasound (HIFU) is a noninvasive thermal ablation technique that uses externally applied ultrasound energy to cause thermal necrosis [9,10]. HIFU has been used clinically to treat uterine fibroids, neurological diseases, and tumors in the prostate, breast, liver, and pancreas, but its clinical use is still infrequent due to anatomic challenges and long procedure times [11-13].

Histotripsy is a noninvasive focused ultrasound technology similar to HIFU [14-17]. However, the underlying mechanism of histotripsy is fundamentally different, relying instead on a mechanical effect at the cellular level to destroy tissue.

.....

histotripsy uses short ultrasound bursts (microseconds in length) with a low duty cycle (≤1%) to minimize heating [19], and higher peak pressure amplitudes to generate acoustic cavitation from endogenous gas in tissues. Acoustic cavitation is the generation, oscillation, and collapse of microbubbles activated by ultrasound [20]. Very high ultrasound pressure causes inertial expansion and collapse of cavitation bubbles that impart localized intense strain that can fracture cells [21] into an acellular debris.

[Bigmls7890 in reply to petabyte]

Primary Mechanism:

Histotripsy: Uses extremely short pulses (microseconds) to create mechanical fractionation through cavitation bubbles

HIFU: Uses continuous or longer pulses to create thermal ablation through heat

Tissue Destruction Method:

Histotripsy: Mechanical breakdown of tissue into subcellular debris through bubble clouds

HIFU: Thermal coagulation causing protein denaturation and cell death

Key Characteristics:

Histotripsy:

More precise boundaries

[Teufelshunde]

Since that article was a year ago, I wonder where they are with this today!

[j-o-h-n]

HIFU....... I just "love" that abbreviation.......That's how I say hello to my ex-wife every time I see her.

Good Luck, Good Health and Good Humor.

j-o-h-n