new trial for mCRPCa: ²²⁵Ac-rhPSMA-10.1 actinium

[Maxone73]

"The trial will enrol male patients with metastatic castrate-resistant prostate cancer who have responded to prior lutetium 177 (¹⁷⁷Lu)-PSMA therapy."

clinicaltrialsarena.com/new...

it's phase 1/2 but actinium is very interesting especially against micro metastasis

[lcfcpolo]

Thank you. Good to see a UK hospital getting involved in Actium AC.

[spencoid2]

why are there no similar trials in the US? i looked at clinicaltrials.gv and found nothing.

my recent EBRT did get rid of most pain but my PSA is climbing at doubling time of 2.9 months and is now at 108 looking for the next treatment and thought actinium looked promising. i responded to lutetium 177 but my blood tests suggested that i needed a break.

[Maxone73 in reply to spencoid2]

I think there will be. It's a new radioligand (there are others on the way from the same research team), preclinical results published this year only and from Munich University, so I suppose they will start in whole europe first, but I am sure that some US party will join soon.

[Maxone73 in reply to spencoid2]

clinicaltrials.gov/study/NC...

Maryland is mentioned

[spencoid2 in reply to Maxone73]

This is for LU 177 not actinium? I was hoping for an actnium treatment with a more specific ligand to avoid xerostomia which seems to be common and scary if permanent. i missed the part about carrying both actinium an chemo together? even better

[Maxone73 in reply to spencoid2]

you are right but keep an eye on it, because both are developed by the same team, so I would expect the same centers to be involved in the trial

[Maxone73 in reply to spencoid2]

have you looked into this?

theranostictrials.org/studi...

is looks very promising form preliminary results

[spencoid2 in reply to Maxone73]

interesting and Stanford is doable. however i am not ineligible for LU 177 unless they say that it fucked me up too much? i only had three and my blood levels got so bad they thought another might kill me so maybe that is ineligible. supposedly today my two oncologists radiologist and another doctor (forget who but think there are 4) are discussing my situation and are developing a plan? When they report back I will mention this possibility.

[Maxone73 in reply to spencoid2]

how long ago have you had 177 Lu??

[spencoid2 in reply to Maxone73]

maybe 4 or 5 months ago. i wrote to the trial doctor

[Cenerus]

this is an interesting drug. If I’m reading the various papers correctly, it uses a molecule that can have two payloads attached to it. In this new trial they will attach Actinium to one binding site, and a form of chemotherapy drug on the other site. This attacks the tumor in two different ways thus forming a PSMA target dublet therapy. Nice concept.

[j-o-h-n]

"enroll male patients" HUH?

Good Luck, Good Health and Good Humor.

j-o-h-n

[Adlon57 in reply to j-o-h-n]

What is a typical "male" patient, these days?🙄

[j-o-h-n in reply to Adlon57]

My twin sister........

Good Luck, Good Health and Good Humor.

j-o-h-n

[Janhpr]

Hi Maxine 73 have you got contact information at UCL Professor Gerhard Attard, my husband had 6 treatments of Lu with good results but unfortunately did not last long

[Maxone73 in reply to Janhpr]

Hi there! I do not know him personally, but here is his email [e-mail] (it's publicly available so I am not damaging his privacy). But normally in the case of clinical trials, everything start with an email from your MO to the trial investigator.