Guardant 360

[ron_bucher]

I’m interested in hearing about anyone using Guardant 360 test results for their treatment decision.

[RJAMSG]

Hello Ron, I’ve not heard of the Guardant 360 yet? Genetics? Link to more information?

[ron_bucher in reply to RJAMSG]

ncbi.nlm.nih.gov/pmc/articl...

[ron_bucher]

Can you share the “false finding” data you refer to? What is HRR?

[ron_bucher]

saliva tests are for mutations we are born with. Guardant 360 is for mutations developed after birth.

[dico]

The Guardant360 pointed my husband to Keytruda due to a MSI-HI result. My husband was a super responder and his cancer has been undetectable since June 2022 after only one infusion of Keytruda.

[EdBar]

I’ve had a few genetic test run over the last few years, the first was a Guardant 360 run by Snuffy Myers several years ago to test for neuroendecrine cancer which thank goodness was negative. Since then Dr. Sartor has run an another Guardant 360 which again showed nothing. He has also ran a couple of Caris genetic tests which turned up 2 germ line genetic mutations, one being CHEK2 which may fall into the category of HRR mutations and make it an option to treat with a Parp Inhibitor and enzalutamide which was recently approved by the FDA. He said there is a current study taking place to refine what is considered a HRR mutation since currently that field is very wide. If CHEK2 falls in that category then I’ve got another bullet in the holster. He has also run a Tempus genetic test recently to check for somatic mutations but it came up negative.

Ed

[ron_bucher]

Did your test results factor into treatment decision(s)?

[j-o-h-n]

Guardant360 is just another way of saying 4 o'clock.......

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 10/31/2023 7:12 PM DST

[Seasid]

Could you add olaparib parp inhibitor during the SBRT of your cancer?

[NanoMRI]

What did you decide on Guardant360 CDx? I am waiting results from my 2nd. First a year ago was clear. Along with clear imaging and very low stable 0.03X range, supports my decision continuing to hold off on further treatments while continuing (perhaps only theoretical) assault on lingering cancer stem cells.

[ron_bucher]

My Guardant360 result was negative.