Lu-PSMA-617 for mCRPC

ncbi.nlm.nih.gov/labs/pmc/a...

[Hidden]

Seems but hasn't. Technically I was never interested in TRT. My interest in that area has been SPT and BAT. I'm doing BAT and working on it daily. But there is a limit to how fast I can test variables. So I look into possible future steps.

[cesces in reply to Hidden]

What is TRT & SPT?

[swwags in reply to cesces]

TRT = testosterone replacement therapySPT = serine palmitoyl transferase

[Hidden in reply to swwags]

They mean many different things.

SPT = supraphiysiologic testosterone

NMD = naturopathic medical doctor. They have a degree.

[cesces in reply to swwags]

Is that low levels of testosterone, compared to supraphiysiologic testosterone?

[Hidden in reply to cesces]

TRT? TRT is testosterone replacement therapy and the typical goal is to get guys with low T up to normal levels. Depends on the guy but somewhere between 600 and 900 ng/dl seems to be the norm. These levels might be the worst ones for guys with PCa. Too low for the double-strand DNA breaks or calcium ion inflow of high testosterone but high enough to give plenty of food to androgen-dependent cancer cells.

Low T would be < around 200 ng/dl. ADT would be < 50 ng/dl and works better if T is closer to zero.

SPT is usually defined as T > 1500 ng/dl. On SPT I like to make sure I'm above 1800 or so to give me a buffer.

BAT is cycling low and high (try to get to zero and then go > 1500 ng/dl). One of the theories is that this prevents PCa from adapting. Another one is that AR amplification occurs during ADT-like low T phases and then the cells are set up for destruction when SPT delivers tons of T. Another one is that we have different "tribes" of cells. Androgen sensitive and Androgen insensitive. There are more androgen-sensitive ones but we don't want to completely destroy either one of them or the other one has a growth advantage.

I read some of the original studies of Huggins and his theories are in line with BAT. He calls it hormonal interference. Castrate T kills PCa cells. SPT also kills them.