Somatic Test UK

[Hillwalker87]

Hello, this is probably more directed at the UK members really; Has anyone had a somatic test and if so, where did you get it done? A member on a previous post has advised that the original biopsy can be used for this, is this what you had done? Thanks again 👍

[Tall_Allen]

You can use it for some readings (like msi-hi/dmmr) but some mutations don't show up until metastases have progressed.

[Hillwalker87 in reply to Tall_Allen]

Thanks TA, so they biopsy the mets then do they?

[Tall_Allen in reply to Hillwalker87]

If they are large enough and accessible.

[Hidden]

I wouldn't advise using the original biopsy, you want the latest mutations. The cancer has been busy working around your treatments so you want to know how it's doing that.

[Curehunter]

My consultant organised somatic testing of the original biopsy tissue and they found BRAC2. However tissue sample was only 6 months old at the time. I believe they used Foundation One.

[GP24]

It is simple to ask the pathologist to send the archived biopsy samples to a genetic lab. I would prefer that to a new biopsy of a metastasis. FoundationOne writes:

Does a new biopsy have to be collected for FoundationOne®CDx?

FOUNDATIONONE®CDx can also be carried out with a tissue sample from a previous biopsy. However, if enough tissue is not available from the previous biopsy to carry out the analysis, another biopsy may be necessary. Sometimes the doctor also recommends a new biopsy in order to obtain a fresh sample.

So usually they use tissue sample from a previous biopsy.

foundationmedicine.de/conte...

[GP24 in reply to GP24]

This study reports: "Sequencing archival, primary prostate cancer tissue may be an accurate means to assess the status of actionable DNA repair gene alterations in men with metastatic disease."

jamanetwork.com/journals/ja...

[lcfcpolo]

Hi. UK based. I have never been offered a biopsy, as presenting PSA was 1,311. I researched this a few months ago. Oncologica in Cambridgeshire offer Genomic profiling. They seemed very professional. Genesis Care also offer the test based on a biopsy and again the replies that I received were very professional. Best of British to your Dad and you.

[Hillwalker87 in reply to lcfcpolo]

Thanks for your response, and the best of luck to you also!