Another possibly positive insight?

[SimonHL]

Although "just" a study in mice but implanted with human Melanoma cells ...

"These findings have several important clinical implications. Not only did we show a viable way to suppress non-genetic resistance, but we also demonstrated that the presence of specific cells dictates which resistance mechanism is likely to occur. This observation is the key to predicting potential resistance routes in patients and developing personalized therapies."

Paper: "Presence of certain stem cells linked to nongenetic resistance mechanisms of cancer cells"

news-medical.net/news/20210...

[Spyder54]

Captured my attention,! Thanks Simon “Now, the team of Prof. Jean-Christophe Marine (VIB-KU Leuven Center for Cancer Biology) shows that the presence of certain stem cells correlates with the development of nongenetic resistance mechanisms. Their study is published in the prestigious journal Cancer Cell.

Two routes to resistance

Even though cancer therapy has made great strides in the last few years, resistance remains a major problem. When cancer cells develop resistance against the drugs targeting them, they can continue to spread, even when the patient is going through therapy.

Until recently, it was thought that this resistance arises exclusively through mutations - genetic alterations - in the cancer cells. However, new studies have suggested that resistance against cancer drugs can also arise via non-genetic mechanisms that change the expression of certain genes without altering the DNA sequence.”

[Spyder54 in reply to Spyder54]

“This signaling pathway depends crucially on the protein Focal Adhesion Kinase (or FAK). By blocking the activity of this protein, the team was able to drastically reduce the occurrence of non-genetic drug resistance in patient-derived xenografts - tumor cells from human patients that were implanted in mice.”

[Spyder54]

Avoiding, or delaying “Castration Resistance” is key here!