Intermittent Orgovyxx?

[Leader4077]

Anybody trying intermittent Orgovyxx? Because it is a daily tablet, seems that it is superior to a 1, 3, or six month shot ...........you can try 4-5 days on, 4-5 days off, not months off.

Clearly, this is not standard of care for this new drug but seems to have great potential to alleviate fatigue without t her extreme risk of stopping for months and raising PSA. Insurance and most docs probably won’t go along with this but You can always spend the $2300. for 30 pills and try it with the right MO.

MB

[GP24]

This will not work. Intermittent ADT lets the testosterone level recover so the patient will feel better. If you stop Orgovyxx for a week and then continue for a week the testosterone level will not recover that much to make you feel better. Firmagon is a very similar drug and testosterone recovery is very slow with that. You will just save 50% of the cost for Orgovyxx.

[Leader4077 in reply to GP24]

Thanks for the reply. One of the reasons I switched from Firmagon to Orgovyxx is the stated claim of Orgovyxx that testosterone recovers MUCH faster with it than any other similar product/injections. How would they know that unless they have some data proving it? That is what I am looking to find.

Mike

[GP24 in reply to Leader4077]

In this study they report: "Three months after discontinuing treatment, 52% of men on relugolix and 16% on degarelix experienced testosterone recovery ".

Further: "recovery was defined as the return of testosterone values to baseline or to >9.8 nmol/l [>280 ng/dl]". >280 isn't a complete recovery. So I do not expect testosterone to recover days after discontinuing relugolix.

europeanurology.com/article...

[Tall_Allen]

Because it's action is so short-lived, you will give your cancer, but not you, breathing room by using this strategy - really bad idea. If you need a vacation from ADT, take more time off, but understand the risk of that.

[JPnSD]

Really dangerous to float these types of theories with no basis. We are lucky to have a clinical study to guide us...why wander in the forest with a blindfold on and risk losing all benefit from the drug?