Genistein

[Garp41]

europepmc.org/article/MED/1...

Comments?

Doug

[Graham49]

There are many studies both for and against genistein. Here's one for. More comprehensive studies are needed. It could depend on dose, type of PCa, whether metastatic etc.

Beneficial effects of genistein in suppression of proliferation, inhibition of metastasis, and induction of apoptosis in PC3 prostate cancer cells

Gholamreza Shafiee, Massoud Saidijam, Heidar Tayebinia & Iraj KhodadadiORCID Icon

Received 10 Jun 2019, Accepted 13 Jan 2020, Published online: 27 Jan 2020

doi.org/10.1080/13813455.20...

Abstract

Objectives: Beneficial effects of genistein have been studied in various cancer types but the underlying molecular mechanisms of its actions have not been well established. This study investigated the effects of genistein on caspase-3 and p38 mitogen-activated protein kinase (p38MAPK) as main cellular signalling targets in PC3 prostate cancer cells.

Methods: Caspase-3 and p38MAPK gene expression and intracellular protein levels were determined. Matrix metalloproteinase-2 (MMP2) gelatinase activity and caspase-3 enzyme activity were measured and PC3 cell migration and proliferation potencies were assessed.

Results: Genistein induced apoptosis by enhancing the gene expression, intracellular protein level, and enzyme activity of caspase-3. Genistein also inhibited cell proliferation by reducing p38MAPK gene expression and protein level and strongly suppressed metastatic potency of PC3 cells by reducing MMP2 activity.

Conclusion: Genistein exhibits its beneficial anticancer properties on PC3 cells by reducing metastatic potency and regulating caspase-3 and p38MAPK pathways at different transcriptional and protein levels.

We would like to thank Hamadan University of Medical Sciences for financial support.

[pjoshea13 in reply to Graham49]

full: sci-hub.do/10.1080/13813455...

see also: healthunlocked.com/advanced...

-Patrick

[RonnyBaby]

There have been 'debates' about 'soy' extracts and the food itself and what is considered moderate consumption.

I have 'deleted' soy and soy supplements from my, menu while others continue.

This article is yet another confounding part of the puzzle.

At least IF I was taking 'soy supplements', I'd certainly think twice about continuing ....

[Gemlin_]

If you eat a varied diet and with a normal soy intake, you do not have to worry about hormonal effects. It is very difficult to reach harmful levels through diet alone. However, one should always be careful with supplements that contain high concentrations. Then you can reach levels that can give a harmful estrogen effect in the body.

[pcmyway]

Here’s the conclusion of the complete study which I have read (in case you’ve only read the abstract:

“Genistein enhances telomerase activity and hTERT transcriptional activity by activating STAT3 and increasing STAT3 binding to the hTERT promoter. These results are particularly alarming because there is a growing trend of consuming unknown amounts of phytoes- trogen-containing dietary products and/or supplements for the prevention and/or treatment of cancer. This study raises a serious concern that instead of beneficial effects, certain physiologically achievable concentrations of genistein could have detrimental effects to individuals with prostate cancer.”

The risk seems apparent and therefore Genistein is not something I would consider.