PT-112

[1965l79Corvette]

Has anyone heard of a treatment trial PT-112?

[pjoshea13]

"... heavily pretreated men with castration resistant prostate cancer exhibited serologic and radiographic responses to PT-112, employed as standalone therapeutic agent11,12 or combined with avelumab,14 an ICB specific for CD274 (best known as PD-L1)15,16 that is poorly active in such patients."

ncbi.nlm.nih.gov/pmc/articl...

-Patrick

[Tall_Allen]

It is a platinum-type of chemo.

clinicaltrials.gov/ct2/show...

[j-o-h-n]

No but I once owned a 65 vette.... stolen however.... It was the fastback stingray Milano maroon.....

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 10/26/2020 12:49 PM DST

[Shooter1 in reply to j-o-h-n]

Mine was a BD-12D----flew real nice.

[j-o-h-n in reply to Shooter1]

Mine was as fast as a little kid falling off your my lap....crawls real nice....

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 10/26/2020 5:05 PM DST

[1965l79Corvette in reply to j-o-h-n]

the 65 vet is a L79 convertible. My treat for being on this group! I have a 69 ss camaro as well.

[j-o-h-n in reply to 1965l79Corvette]

This is no BS but I also had a 69 camaro which I bought at auction after they stole my vette . Candy apple red with a black racing stripe across the front of the hood (left to right from fender to fender). It was only a 6 cyl with white interior... Gave it to my nephew.

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 10/26/2020 4:49 PM DST

[dockam in reply to j-o-h-n]

Had an Electron Blue 2003 Z06, but alas no more. I do have a '57 Belair being worked on by a patient.

[j-o-h-n in reply to dockam]

nice rides............ 57 Belair was referred to as the "baby cadillac"......Those were the days...Good luck with the Chevy...

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 10/26/2020 6:05 PM DST

[ctflatlander in reply to j-o-h-n]

The 32 Chevy was known as baby cadillac also. The 32 and the 57 were known as best collectible chevy's. Sold my 32 a couple yrs ago after owning it for 44 yrs.

[j-o-h-n in reply to ctflatlander]

32 Chevy coup... is sweet.... Thanks for reminding me....

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 10/27/2020 4:52 PM DST

[Kaliber in reply to j-o-h-n]

I had the 68 Pontiac firebird HO Hurst. Same sheet metal as the Camaro. It had the Hurst stripes, shifter , hood tach, suspension etc. L76 327 , 365 HP Chevy solid lifter engine . It originally had a larger engine in it with lower hp but was wrecked and the original motor replaced . Alas, I waived good-bye to it when my 2nd wife and myself split for good yayahahahaya dang fine car tho ... very exciting to drive.

[j-o-h-n in reply to Kaliber]

I remember the Bird.... nice but today it would be politically incorrect to own one. Chief Pontiac is a no no..... (racist not racer's car)... My ex-wife got my 1951 Buick Special.... with dynaflow... put it in gear and wait 5 seconds to engage.... (just like my ex-wife) LOL

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 10/26/2020 6:11 PM DST

[Kaliber in reply to j-o-h-n]

Yayahahahaya sometimes there is no justice.😂😂😂😂

[j-o-h-n in reply to Kaliber]

no Justice no piece.......

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 10/26/2020 8:19 PM DST

[1965l79Corvette in reply to Kaliber]

My Camaro was a line item in my divorce. Husband keeps the 1969 Camaro. LOL!

[Kaliber in reply to 1965l79Corvette]

Lucky you. Wife with the child gets everything were I lived at the time yayahahahaya. All court decided . The guy in line in front of me seeing the divorce court judge ...wife awarded a lot of support. The guy said, “ but your honor, I don’t even gross that much money “ .... , judge says “ better get two jobs son !!! “ . Yikes yayahahahaya thought I was screwed. Judge gave her everything we owned including TV set , my car , guns, everything ... and 60% percent of my monthly Army payroll check. Lucky I was able to live on base and eat at the mess yayahahahaya.

[SPEEDYX in reply to Kaliber]

Where is Voltaire Perkins when you need him!!!

[Kaliber in reply to SPEEDYX]

Exactly yayahahahaya ( had to look him up on web )

[SPEEDYX in reply to Kaliber]

Original Divorce Court on TV in the sixties I was intrigued by it and watch after coming home from school

[Kaliber in reply to SPEEDYX]

I probably saw the show .. Lupron fog. The great thing about Lupron fog is that you can play oculus quest mystery puzzle games over and over and not remember how you solved it last time. Yayahahahaya

😂😂😂😂🌸🌈🌻🦋🌵🌵

[SPEEDYX in reply to Kaliber]

😂....well I have my fog lights on hopefully it wont come for a long time!!

[Kaliber in reply to SPEEDYX]

💪💪💪👍👍👍

[Shooter1 in reply to Kaliber]

And your library only needs three of your favorite books. Lots of luck

[Kaliber in reply to Shooter1]

Yayahahaha yayahahaha yea, how handy is that !!!

[j-o-h-n in reply to 1965l79Corvette]

Smart move on your part......... but I got visitation rights for my 51 buick....

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 10/26/2020 8:23 PM DST

[Gearhead in reply to 1965l79Corvette]

Mine was 1965 coupe with FI (the 375-hp 327) and OEM KOs. Bought for $3,500 in 1969, sold for $8,500 in 1978, and thought I'd made a killing. Current daily driver is a C6. Hang on to that Camaro.

[1965l79Corvette in reply to Gearhead]

Yes I am keeping the Camaro. My daughter will have it one day She helped me wet sand it 20 years ago when she was 5 when we where restoring it. She is now 25 and a radiation therapist. She became that she said to help stop the cancer that is after me. So proud of her!

[j-o-h-n]

Please tell us your bio. Age? Location? Treatment(s)? Treatment center(s)? Scores Psa/Gleason? Medications? Doctor's name(s)? Thank You!!!

All info is voluntary, but it helps us help you and helps us too. If you do respond copy and paste it in your home page for your use and for other members’ reference.

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 10/26/2020 12:51 PM DST

[1965l79Corvette in reply to j-o-h-n]

2011 PSA 28 Gleason 9/10 on all samples Radiation, true beam, 2011, Lupron 2011 to present, Chemo Taxoterre 2016-2017 ,Zytiga 500mg 2017 to 2018 , Provenge 2018, I forget the name of the med 2019, Hopkins combatTrial 2019-20120 (failed) PSA went from 6 to 256 in April 2020. Chemo Jevtana/carboplatin 4/2020-present (PSA went from 256 down to 120 now back to 189. Waiting for lu177 trial. They have also offered PT-112 . Nodes are smaller but bone spine are bad. Losing hope.

[j-o-h-n in reply to 1965l79Corvette]

Thank you for the quick detailed reply. Looks like your psa is acting like a yoyo. Please do NOT lose hope... You will be around for many many years, like many of the guys here. Just keep plugging away and kill those tiny bastards. You have come to the right place for up to date info and camaraderie. Keep posting, the brotherhood is here to help.....

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 10/26/2020 4:44 PM DST

[1965l79Corvette in reply to j-o-h-n]

So hard. 10 years. had to retire move give up my charter fishing business. bone pain has started. sick of being sick...

[j-o-h-n in reply to 1965l79Corvette]

I can understand.... fishermen "highest" death rate of any job.... Mention pain in a new post for many many suggestions from the group.....

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 10/26/2020 4:53 PM DST

[Survivor1965 in reply to 1965l79Corvette]

Hello Corvette,

Just curious where your bone pain is? Ive been 9 years on ADT and now tons of pain in my back and what seems like joints. What do you have going on?

Many thanks,Johnny

[1965l79Corvette in reply to j-o-h-n]

Extandi wasthe treatment in 2019

[1965l79Corvette in reply to j-o-h-n]

age 62, Virginia, Anne Arundel Medical Center, Johns Hopkins. Trial will be in New York

[j-o-h-n in reply to 1965l79Corvette]

Thank you for your information,,,, Where in NY?

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 10/27/2020 4:55 PM DST

[Faith1111]

ir.arvinas.com/news-release...

Have you been tested for any mutations? My brother will begin this phase 1/2 trial in early November. Having known mutations is not a requirement of the trial however they found that the AR Degrader seems to respond better with certain mutations. My brother also failed Xtandi and Zytiga. He did Provenge and Docetaxel. He will be doing the trial at Yale New Haven Hospital in Connecticut. Mass General in Boston is also conducting the trial as are many other places I believe. Some thing you may want to look into.

[1965l79Corvette in reply to Faith1111]

Tested twice no mutations were found.

[1965l79Corvette in reply to 1965l79Corvette]

Just reread, he hasn't started yet.

[1965l79Corvette in reply to Faith1111]

Thank you for the information. It gives me a better understanding and hope. Is your brother responding well? Thank you

[MateoBeach]

Yes, agree it’s a good idea to ask if there is a biopsy accessible met to get tumor (somatic) genetic testing. Good luck and keep cruising with shiny side up.

[1965l79Corvette in reply to MateoBeach]

Johns Hopkins took biopsy and would NOT share any information during COMBAT trial.

[Cleodman]

I participated in a clinical trial involving PT-112 which is a new platinum based chemotherapy combined with the immunotherapy agent avelumab. Infusions every 2 weeks. I did not tolerate the side effects well but regardless it did nothing to slow the progression of my disease. My PSA more than tripled in 2 months and plenty of new metastatic lesions and progression of lymphadenopathy. I’m obviously biased with this clinical trial but I would file my experience under rotten and ineffective.

[1965l79Corvette in reply to Cleodman]

Ugh. Thank you for your response. I am in the same boat.

[monte1111]

Wishing you, and everyone else in this boat, the best.

[billyboy3]

I too have a vet, a 1965 convertible, with a 396, m22 transmission, let. a kid take her out and he hit two telephone poles at 70 mph and blew her up into a million pieces, $80,000 gone in a mere flash!!!!

[1965l79Corvette in reply to billyboy3]

Sad

[billyboy3]

well, it was only money but the kid survived, not that he deserved to because he put lives at risk driving like that in the city!! I had just had her redone, paint was still curing, a brand new exhaust system put on 10 hours earlier, it took two tow trucks to move it, as had to lift it onto a trailer front and back. The car got hit in the side, then spun into a large pole, then did a 360 the other way, took out a bus stop seat, and just exploded. The muncie m22 rock crusher transmission-also just rebuilt, was destroyed when the car hit the pole at the drivers side door post, bent the 1 1/2" tran shaft, the hood went thru a fence 150 ft away, fuel tank ended up down the road.