Mighty Mouse - PCa mice doing better lifting weights

[Ausi]

Abstract 3481: Continuous load bearing exercise inhibits the development of prostate cancer bone metastasisesults: In the continuous mechanical loading group, tumours were detected in non-loaded tibias in all 12 mice (100%), whilst 8 out of 12 mice showed reduced skeletal tumours in the loaded tibias (67%), with 4 having no tumour in the loaded leg (33%). Tumour burden (Flux: photon/second) in the non-loaded tibias was 134% higher than that in the loaded tibias. Micro-CT analysis suggested that loaded tibias had significantly increased trabecular (BV/TV) and cortical bone volume and trabecular thickness (Tb.Th) (p<0.001). Surprisingly, treadmill exercised mice had higher tumour burden (~91%) in the hind limbs compared to the sedentary controls (P<0.05), with no statistically significant improvement in bone mass examined by micro-CT. In the loading withdrawal group, 6 out of 8 mice (75%) showed larger tumour size in the loading withdrawal tibias than in the non-loaded tibias, while only two mice (25%) had smaller or no tumour in the loading withdrawal tibias. Tumor burden were ~90% higher in the loading withdrawal tibias (p<0.05, t-test). This is associated with fast diminishing osteogenic response within a week after ceasing the loading stimulus, confirmed using micro-CT analysis by comparing percentage changes of BV/TV and Tb.Th among baseline, 1-week loading, and loading withdrawn groups.

Conclusion: The continuity of high-intensity load bearing exercise is critical to prevent PCa growth in bone, possibly via maintaining the balance of bone remodelling towards osteoblastic bone formation. Mild aerobic exercise evaluated here was unable to significantly improve bone mass or achieve the benefits in inhibiting PCa bone metastases observed with high intensity loading.

Ning Wang, Hector M. Arredondo, Alexandria R. Sprules and Colby L. Eaton

DOI: 10.1158/1538-7445.AM2020-3481 Published August cancerres.aacrjournals.org/...

[dockam]

My MO was surprised with my PSA at 840.2 in 2015 that I didn't have more mets (only left ureter lymph nodes) and especially no bone mets.

He speculated that since I was a marathoner it prevented the spread of PCa to my lower limbs.

Also, that fitness level allowed me to endure 15 Taxotere sessions( instead of the CHAARTED protocol of 6) and not have any neuropathy possibly due to the increased vascularzation of the distant blood vessels.

My best to you Brother

Randy

[Currumpaw in reply to dockam]

Hey dockham!

One name--Dr. Ruth Heidrich!

Currumpaw

[j-o-h-n]

My cat lifts mice............

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 08/24/2020 1:19 PM DST

[Ausi in reply to j-o-h-n]

Watch out John, if your mice read this they might just chuck that cat out the window, Tom and Jerry?