I had genetic testing done by my oncologist. They came back with results that said I had no known mutations. At that point, the conversation basically transitioned away from genetics but I wonder if there is more that can be done with genomic sequencing: These videos inspire action but I'm just not sure what can be done with sequencing that wasn't tested in my initial genetic testing. Is there a deeper level of testing that can be done to identify precision medicines for each individual patient?
But is there a difference between general generic testing vs specific sequencing of tumor samples? I think Bryce Olson is testing specific samples of tumors. It sounds like that is different then just general genetic testing.
I just got my results back for genetic testing and got same results: no known mutations found. Besides doing it for me and future treatment possibilities, I had it done especially for my children. Of interesting note to others, the gen tester said that Kaiser will approve testing for anyone that is metastatic.
One sad observation i have about this site is that i can ask a question about immunology which could be really help someone improve their cancer status and i get 2 replies but when i post about egg whites I get 50 replies. You'd think it would be the other way around.
My husband similarly this week received his results back from genetic testing which stated 'no pathogenic variants were detected'.
He was tested for 14 strands...TTM (c.7271T>G only), BRACA1,BRACA2,BRIP1, CDH1, CDKN2A, CHEK2,HOXB13, PALB2, PTEN, RAD51C, RAD51D, STK11, TP53.
The geneticist we saw had previously been an oncologist and knew a considerable amount about PC treatments.
She did mention that further testing, and I was a bit lost at this point, but I think she meant of tissue from his mets might give further insight and maybe mutations, but she didn't push to have that done and we didn't know enough about where this line of thinking was going to pursue it further.
Others on this site no doubt will have better understanding and will provide you with more specific advice.
From what I'm told it's very helpful not to have BRACA1 or 2 both in relation to the progression of PC and also in relation to family members like sons and daughters.
As the wife of a daughter and husband that have BRCA2, I agree that although there are additional treatments available if you have it, it is not something you should wish for. My daughter had a double mastectomy at 35 just 9 months after she was married for the first time. The chances that your children would inherit this gene defect are 50/50 if one of the parents have it. Just want to add that our daughter is doing well after 7 years and my husband has been on Lynparza going on 3 years after being diagnosed in 2004. Not everyone with BRCA2 is so lucky.
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