Thoughts? (Cancer Bush)

[KingNeptune]

I'm seeking thoughts, knowledge and any experience from forum members on Sutherlandia Frutescens (cancer bush). I did a search, but couldn't find any prior posts. It is available on the internet and it all appears to be from S. Africa where it is a native plant. It is available as a extract or in capsule form. I have not been able to find a product label showing GRAS. I've already done research on this, but I would like input from fellow forum members.

[Graham49]

hedgehog signaling in prostate cancer cells by “cancer bush” Sutherlandia frutescens extract

Hui Lin Glenn A. Jackson Yuan Lu Sara K. Drenkhahn Korey J. Brownstein Nicholas J. Starkey William R. Lamberson Kevin L. Fritsche Valeri V. Mossine Cynthia L. Besch‐Williford … See all authors

First published: 17 September 2015

doi.org/10.1002/cbin.10544

Citations: 3

Present address of Cynthia L. Besch‐Williford is IDEXX RADIL, Columbia, Missouri 65201, USA.

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Abstract

Sutherlandia frutescens is a medicinal plant, traditionally used to treat various types of human diseases, including cancer. Previous studies of several botanicals link suppression of prostate cancer growth with inhibition of the Gli/hedgehog (Gli/Hh) signaling pathway. Here we hypothesized the anti‐cancer effect of S. frutescens was linked to its inhibition of the Gli/Hh signaling in prostate cancer. We found a dose‐ and time‐dependent growth inhibition in human prostate cancer cells, PC3 and LNCaP, and mouse prostate cancer cell, TRAMP‐C2, treated with S. frutescens methanol extract (SLE). We also observed a dose‐dependent inhibition of the Gli‐reporter activity in Shh Light II and TRAMP‐C2QGli cells treated with SLE. In addition, SLE can inhibit Gli/Hh signaling by blocking Gli1 and Ptched1 gene expression in the presence of a Gli/Hh signaling agonist (SAG). A diet supplemented with S. frutescens suppressed the formation of poorly differentiated carcinoma in prostates of TRAMP mice. Finally, we found Sutherlandioside D was the most potent compound in the crude extract that could suppress Gli‐reporter in Shh Light II cells. Together, this suggests that the S. frutescens extract may exert anti‐cancer effect by targeting Gli/Hh signaling, and Sutherlandioside D is one of the active compounds.