Axumin - false positives

[pjoshea13]

Newish paper below [1].

"We present 4 cases of patients who underwent F-fluciclovine PET for prostate cancer demonstrating physiologic uptake in the celiac ganglia, which could be mistaken for metastatic lymphadenopathy if the celiac ganglia have a nodular configuration and uptake higher than bone marrow."

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/312...

Clin Nucl Med. 2019 Sep;44(9):743-745. doi: 10.1097/RLU.0000000000002693.

18F-Fluciclovine Uptake in Celiac Ganglia: A Pitfall in Prostate Cancer PET Imaging.

Wo S1, Matesan MC.

Author information

1

From the Department of Radiology, University of Washington, Seattle, WA.

Abstract

We present 4 cases of patients who underwent F-fluciclovine PET for prostate cancer demonstrating physiologic uptake in the celiac ganglia, which could be mistaken for metastatic lymphadenopathy if the celiac ganglia have a nodular configuration and uptake higher than bone marrow. Uptake in celiac, cervical, and sacral ganglia has been reported previously as an important pitfall in Ga-PSMA-HBED-CC PET for prostate cancer. In our patients, only celiac ganglion uptake was visualized. Advances in PET scanner technology may cause physiologic uptake of F-fluciclovine in celiac ganglia to become more visually distinguishable from muscular uptake in adjacent diaphragmatic crura.

PMID: 31283598 DOI: 10.1097/RLU.0000000000002693

[Indexed for MEDLINE]

[VictoryPC]

Perfectly stated. I like to look at my cancer as a simple thing.