I found this very enlightening article concerning 5-Lox inhibitors

[AlexPaulsen]

ncbi.nlm.nih.gov/pmc/articl...

[snoraste]

Patrick has several posts on the subject as well. If he hasn't seen it already, I'm sure he'll be interested. I have started taking it two months ago.

[rassusukumaran in reply to snoraste]

Please explain. What is it that you have started taking two months ago as per your post?

[snoraste in reply to rassusukumaran]

It’s a 5-lox inhibitor:

lifeextension.com/Vitamins-...

[Hidden in reply to snoraste]

It says only standardized 20%, seems like a very low dose. Boswelia (Indian Frankincense) is described as a 5-Lox inhibitor. Amazon: tinyurl.com/y4jvk34g

[snoraste in reply to Hidden]

I don’t know what the “right” dosage is, if any. I’d like to see any paper on it if you are in possession of it.

[snoraste in reply to Hidden]

It's a question of bio- availability.

[rassusukumaran in reply to snoraste]

Thanks for your response and info. Are we saying that this Life Extension product is the same or similar to . the inhibitor MK591 identified by the researchers.

[Hidden in reply to rassusukumaran]

Sorry I don't have any dose information for use in this situation. This is the problem I see time and again with alternative therapies using supplements there is little if any info about how much might be effective. Typical daily dose on the label would likely be minimal and yet how much to take is left up to the user.

[snoraste in reply to rassusukumaran]

I'm not sure. There are several types of 5-LOX inhibitors. This is based on Boswellia.

[CalBear74 in reply to snoraste]

What is your dose/frequency? Before a meal or after?

[snoraste in reply to CalBear74]

I just take one a day before bed.

[CalBear74 in reply to snoraste]

Who makes this pill? That is, what is the brand? How many milligrams in a single pill?

[snoraste in reply to CalBear74]

Life extension - all the info is on their web site

[pjoshea13]

Alex,

Ghosh was the partner of Dr Myers in 5-LOX studies from 1997 to 2002 [1]-[7], & more recently 2010 [8].

-Patrick

[1] ncbi.nlm.nih.gov/pubmed/919...

[2] ncbi.nlm.nih.gov/pubmed/943...

[3] ncbi.nlm.nih.gov/pubmed/978...

[4] ncbi.nlm.nih.gov/pubmed/103...

[5] ncbi.nlm.nih.gov/pubmed/106...

[6] ncbi.nlm.nih.gov/pubmed/109...

[7] ncbi.nlm.nih.gov/pubmed/126...

[8] ncbi.nlm.nih.gov/pubmed/199...

[jdm3]

If I recall correctly, Boswelia Serrata is a good supplement for this. There are some previous posts about this.

Edited to add, I tried to do a search on the forums, but did not find anything. No time now to dig deeper.

[AlexPaulsen]

I also take a baby aspirin 2-3 times a day as aspirin is also a 5-Lox inhibitor.

[Ralph1966 in reply to AlexPaulsen]

Baby aspirin is 81 mg per each tablet. We take this low dose aspirin to prevent platelets from forming clots. Taking it 81 mg X 3 times will not work as an antiplatelet and become anti-inflammatory (NSAID).

Why not take regular aspirin 320 mg?