Adding Erleada (apalutamide) to first-line ADT significantly extended survival and delayed disease progression.

[Moespy]

FYI... Good news update for this drug in ongoing Phase 3 TITAN Trial. Article here:

prostatecancernewstoday.com...

[Ahk1]

Thank you very much Moespy, great article

[NPfisherman]

Thanks for posting, Moespy... let the arsenal grow.... kill the beast...

[Moespy]

This link has more indepth results and application info....

onclive.com/web-exclusives/...

[savingdaddy]

I printed it. Thanks

[Twoofus]

I have read several articles on this trial and the reported results. I have no idea where this will lead, but apalutamide added to a first line ADT may offer many of us a tremendous. I look forward to the posting of many additional comments as more information becomes available.

I believe I would try this treatment now if I could either get in a trial or convince my MO to put me on such a drug combination. It sounds superior to the multitude of different treatments many of you have been through.

Best thoughts to everyone.

[Moespy in reply to Twoofus]

Hi Twoofus,

I saw you mentioned clinical trials in your reply (this drug not yet available from doctors). The link below will take you to a list of trials involving apalutamide. Each trial has a list of criteria for inclusion. You can use the criteria and the margin check boxes to narrow down what might be of interest and pursue if desired.

Best wishes!

clinicaltrials.gov/ct2/resu...

[GP24]

You have to have metastases and not be castration-resistent according to the TITAN study to use Erleada.

[Moespy in reply to GP24]

Thanks GP24.

Many current clinical trials utilizing apalutamide for castrate resistant also. I believe they are hoping this will be one of the drugs that can be used on both ends of castrate.

Here is a list that includes those trials (same link as my reply above to Twoofus):

clinicaltrials.gov/ct2/resu...

[rococo]

Would xtandi be just as effective in in this scenario, even without the adt. Who knows? Rocco

[Moespy in reply to rococo]

Definitely not an expert at interpreting what I find on the subject but here is what I think I understand. Xtandi is for metastatic and apalutamide is for non-metastatic both to be used in conjunction with ADT in castrate resisitant condition. I believe that is why apalutamide is a first line defender and xtandi is a second line. Might be in over my head but I believe that is the current state of these meds.

[Moespy]

Definitely not an expert at interpreting what I find on the subject but here is what I think I understand. Xtandi is for metastatic and apalutamide is for non-metastatic both to be used in conjunction with ADT in castrate resisitant condition. I believe that is why apalutamide is a first line defender and xtandi is a second line. Might be in over my head but I believe that is the current state of these meds.

[cfrees1 in reply to Moespy]

Yes, I think that is current thinking. I had local nodes removed via open RP and since have no evidence of mets but did have rising PSA while on Lupron so I am now on Apalutamide. So that fits in with your understanding, castrate resistant and no mets.