Cardiff Aspirin Study

[SimonHL]

A landmark observational study by Cardiff University of over 520,000 cancer patients has shown:

- at any time following the diagnosis of some cancers the proportion of patients who were still alive was 20-30% greater in those taking aspirin, and

- the spread of cancer to other parts of the body was also substantially reduced in patients using aspirin.

I briefly discuss this study along with Resolvins here: bit.ly/AspBlog

Simon

[Hazard]

Interesting stuff Simon. Is it too late to start taking aspirin when you are Stage 4? What is recommended.mended dose for aspirin?

[pjoshea13]

Simon & all,

Link to full text:

journals.plos.org/plosone/a...

{Warning for those who dislike meta-analyses - yes, it's another one - there have been at least 10 with a PCa link.]

Here is the section on PCa:

"Prostate cancer

"Our searches identified 16 observational studies, listed in Table 1 and in our earlier report. [18] Fifteen focused on prostate cancer mortality and in ten the index of association suggested a reduction associated with aspirin, significant in three. In five studies the measure of association with aspirin exceeded 1.00, and in one the excess in prostate mortality with aspirin is significant.

"A pooled HR based on the thirteen studies that report the association with aspirin using this index is 0.87 (95% CI 0.73, 1.05; heterogeneity p<0.0005 and Egger’s test P = 0.13). The omission of one out-lying study [53] gives HR 0.84 (95% CI 0.77, 0.92; heterogeneity p = 0.17; see S3 File).

"Evidence on metastatic spread in prostate cancer associated with aspirin, comes from four studies. Pooling three of there, gives RR 0.52 (0.39–0.68), and another study [38] gives HR 0.23 (0.06, 0.91).

"Five studies on prostate cancer also reported all-cause mortality and three show a reduction associated with aspirin, significant in two. However, in two other studies [41,55] the association with aspirin exceeded 1.00 and was significant in both. Four studies report the association with aspirin as hazard ratios and together these give HR 0.84 (95% CI 0.54, 1.30; heterogeneity P<0.0005 and Egger’s test for bias P = 0.42). The omission of one outlier [55] removes heterogeneity and gives for all cause mortality in the prostate studies, HR 0.73 (95% CI 0.66, 0.81; see S3 File).

"The evidence on prostate cancer is therefore fairly consistent for both prostate cancer mortality, and the hazard ratio for all cause mortality also suggests benefit. Correspondence with the author of the one report that is seriously inconsistent [55] led to no clue as to why it differs markedly from the other studies. The reduction in metastatic spread associated with aspirin is otherwise marked and consistent. In one report [42], it is suggested that some inconsistencies in studies of this cancer may be introduced by a selective up-take of PSA (prostate specific antigen) screening, leading to bias resulting from an early diagnosis of cancer in subjects taking aspirin."

For me, the reason for using low-dose aspirin daily would be to stop "metastatic spread".

That is because I believe that micro-clots may be essential for metastasis. Aspirin, as opposed to other NSAIDs, inhibits the aggregation of platelets - the first step in clot formation. & it does this at the standard U.S. low dose.

I prefer to use nattokinase to remove clots that do occur.

Looking back, I seem to have a lot of aspirin posts. Here is one from 2 years back:

healthunlocked.com/advanced...

-Patrick

[Bluebird11 in reply to pjoshea13]

Hi Patrick.. often I read something like this and yet feel confused. Are you saying you personally would take an aspirin and natto...

We do natto.. and aspirin was taken for quite a long time. I have to check if he is still taking an aspirin a day...

thanks

[pjoshea13 in reply to Bluebird11]

I don't see the need for aspirin if taking nattokinase & monitoring D-dimer. I don't use aspirin. I don't like that it can cause kidney damage (as well as stomach).

-Patrick

[sammamish]

I wonder about nattokinase, it is a large protein molecule, one would think it would be highly degraded and digested in the chyme of the stomach

[Stegosaurus37]

Lo these many moons ago my primary care guy suggested I take a baby aspirin a day for cardio. Sure, why not? So I did so and after a couple of weeks I started getting uncontrollable nose bleeds to the extent cauterization was needed. Stopped the aspirin and haven't had a nosebleed since.

Aspirin does work for most people but be careful.

[j-o-h-n]

Aspirin gives me a headache.

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 11/16/2018 6:14 PM EST