Sunitinib

[wrando]

Has anyone here taken sunitinib. It's part of a trial I am considering and was wondering about side effects.

[Tall_Allen]

I think this class of drugs (tyrosine kinase inhibitors) has significant toxicity risk. They should go over the toxicity risk with you.

dovepress.com/risk-of-treat...

Will it be combined with docetaxel?

[wrando in reply to Tall_Allen]

No it would be combined with some psma related vaccine...this is the trial....A Phase 1 Study To Evaluate The Safety, Pharmacokinetics And Pharmacodynamics Of Escalating Doses Of A Vaccine-based Immunotherapy Regimen (Vbir) For Prostate Cancer (Pf-06753512)

[Tall_Allen in reply to wrando]

I asked because sunitinib, given as a single agent, did not test out very well. But this clinical trial is on a whole different level. For those who don't know, it has several components:

1. A PSMA-based vaccine (administered with electroporation) to elicit an immune antibody response to PSMA, which is (mostly) unique to prostate cancer cells.

2. tremilimumab- (similar to Yervoy) - which prevents the immune system from eventually shutting off its response as it normally would.

3. sunitinib- which inhibits an important growth factor for tumor cells

I think this kind of multimodal therapy is very promising, and looking at the list of participating institutions, obviously a lot of others believe in it too. I encourage others to talk to their oncologists to see if they qualify.

clinicaltrials.gov/ct2/show...

[Kevinski65 in reply to wrando]

Where's the trial?

[wrando in reply to Kevinski65]

Yale New Haven hospital CT

[wrando]

It has different arms...I don't know which treatment I would get.