Hormone Sensitive

[Blair77]

Are their studies to read on average how long men diagnosed with de novo metastatic disease respond to ADT?

[Tall_Allen]

About 2 1/2 years median.

[pjoshea13]

You mean ADT as monotherapy? Adding an androgen receptor antagonist, e.g., should increase the time to resistance. There seems to be great interest in combinations & timing now that there are more drugs to work with.

Also, a lipophilic statin plus Avodart block certain avenues of resistance. & I'd add Metformin.

-Patrick

[Blair77 in reply to pjoshea13]

He had upfront Docetaxel, and is on casodex and Lupron. He just started metformin by coincidence because he has diabeties.

[FCoffey]

The average is about 2 years but that includes men whose PSA never goes below 20, and men who stay on ADT with PSA well below 1 for 5 or even 10 years. Averages don't tell you much, every patient and every cancer is different.

I agree with Patrick and Nalakrats. Metformin is cheap, safe, and appear to provide significant benefits to at least some men. It is quite rare to be hurt by Metformin.

Avodart (dutasteride) is also well tolerated by most men, and helps block the conversion of any remaining testosterone to DHT, which appears to promote cancer as well as inflammation of the prostate (which promotes cancer.)

I don't have any experience or decent knowledge of androgen receptor antagonists, and I'm deeply suspicious of statins, but that's just me.