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Advanced Prostate Cancer
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New Italian study below [1].

I posted a review of PCa-coffee research 10 months ago:

"Foods/Supplements-Vitamins: Coffee"

There seems to be no doubt, from studies published in the past 7 years, that coffee drinkers obtain some protection. & so I find the opening to the new study to be odd:

"Meta-analytic data on the effect of coffee in prostate cancer risk are controversial."

{From the latest meta-analysis (2016) [2]:

"105 individual prospective studies were included. Inverse associations were observed on oral, pharyngeal, colon, liver, prostate, endometrial cancer and melanoma". But not for lung cancer.}

Also odd, is the focus on caffeine, which has been ruled out as having a major role, since decaf drinkers also receive protection.

Anyway, regarding "Italian-style coffee":

"newly diagnosed prostate cancer participants presented lower coffee consumption (60.1 ± 51.3 g/day) compared to the disease-free population (74.0 ± 51.7 g/day) "

"Multiadjusted analysis showed that the subjects at highest consumption (>3 cups/day) had 53% lower prostate cancer risk as compared to participants at the lowest consumption (0-2 cups/day)".

The study also found that:

"human prostate cancer cell lines treated with caffeine showed a significant reduction in their proliferative and metastatic behaviors"

but, whatever effect caffeine might have, it seems a basic mistake in the human study to have not distinguished between decaf & regular drinkers.

"Italian-style coffee" is mentioned 3 times. Could that exclude decaf perhaps?

Or do they simply mean "espresso", which, like Swedish boiled coffee, preserves the volatile oils removed by paper filters.

Regardless, it's yet another positive finding for coffee.


Of more interest is how coffee might affect survival. This is from my old post:

[3] (2011 - U.S.) "47,911 men in the Health Professionals Follow-up Study who reported intake of regular and decaffeinated coffee in 1986 and every 4 years thereafter. From 1986 to 2006, 5035 patients with prostate cancer were identified, including 642 patients with lethal prostate cancers, defined as fatal or metastatic."

"Men who consumed six or more cups per day had a lower adjusted relative risk for overall prostate cancer compared with nondrinkers (RR = 0.82 ...)"

"The association was stronger for lethal prostate cancer (consumers of more than six cups of coffee per day: RR = 0.40 ..."

"The inverse association with lethal cancer was similar for regular and decaffeinated coffee (each one cup per day increment: RR = 0.94 ... for regular coffee and RR = 0.91 ... for decaffeinated coffee ..."

"We observed a strong inverse association between coffee consumption and risk of lethal prostate cancer."

This study suggests that coffee consumption perhaps becomes more important after PCa initiation.


[1] ncbi.nlm.nih.gov/pubmed/284...

Int J Cancer. 2017 Apr 24. doi: 10.1002/ijc.30720. [Epub ahead of print]

Reduction by coffee consumption of prostate cancer risk: Evidence from the Moli-sani cohort and cellular models.

Pounis G1, Tabolacci C2, Costanzo S1, Cordella M2, Bonaccio M1, Rago L3, D'Arcangelo D4, Filippo Di Castelnuovo A1, de Gaetano G1, Donati MB1, Iacoviello L1,5, Facchiano F2; Moli-sani study investigators6.

Author information


Meta-analytic data on the effect of coffee in prostate cancer risk are controversial. Caffeine as a bioactive compound of coffee has not yet been studied in deep in vitro. Our study aimed at evaluating in a population cohort the effect of Italian-style coffee consumption on prostate cancer risk and at investigating in vitro the potential antiproliferative and antimetastatic activity of caffeine on prostate cancer cell lines. 6,989 men of the Moli-sani cohort aged ≥50 years were followed for a mean of 4.24 ± 1.35 years and 100 new prostate cancer cases were identified. The European Prospective Investigation into Cancer and Nutrition-Food Frequency Questionnaire was used for the dietary assessment and the evaluation of Italian-style coffee consumption. Two human prostate cancer cell lines, PC-3 and DU145, were tested with increasing concentrations of caffeine, and their proliferative/metastatic features were evaluated. The newly diagnosed prostate cancer participants presented lower coffee consumption (60.1 ± 51.3 g/day) compared to the disease-free population (74.0 ± 51.7 g/day) (p < 0.05). Multiadjusted analysis showed that the subjects at highest consumption (>3 cups/day) had 53% lower prostate cancer risk as compared to participants at the lowest consumption (0-2 cups/day) (p = 0.02). Both human prostate cancer cell lines treated with caffeine showed a significant reduction in their proliferative and metastatic behaviors (p < 0.05). In conclusion, reduction by Italian-style coffee consumption of prostate cancer risk (>3 cups/day) was observed in epidemiological level. Caffeine appeared to exert both antiproliferative and antimetastatic activity on two prostate cancer cell lines, thus providing a cellular confirmation for the cohort study results.

© 2017 UICC.


antineoplastic activity; caffeine; coffee; prostate cancer

PMID: 28436066 DOI: 10.1002/ijc.30720

[2] ncbi.nlm.nih.gov/pubmed/276...

[3] academic.oup.com/jnci/artic...

13 Replies


I drink coffee and tea for the taste, enjoyment, and energy boost. For most Americans it is the biggest intake of antioxidents consumption for the day. I drink two to four cups a day, 8 oz. cup volume.

I enjoy your articles, and find them informative.


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Interesting, I have been a heavy caffeinated coffee drinker since about age 24. Drinking a pot (8-12 cups per day) until about age 58 and i still drink about 4-6 cups a day of caffinated coffee at age 73. I was diagnosed with prostate cancer 18 years ago and have been under treatment since. A summary of my treatments are in my profile. Quality of life is still pretty good, considering my age.

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There's only so much green tea (in my case, white tea) & coffee a guy can consume, especially post RP & EBRT, without spending his life peeing. What do you do, drink coffee & take lightly caffeinated green tea supplements? Do you happen to know if similar coffee supplements exist? Thanks.

And thanks, as always, for all you do for us.




I used the LEF green tea extract for many years. Each cap = 6 cups. I was using 4 caps, not realizing that the liver might have a problem with 2. I don't see evidence that drinking 6 cups of green tea is worth a hill of beens! 2 caps - divided dose - might have benefit. But there are other polyphenols (than EGCG) with greater potential benefit IMO. You can't take everything - unless you are Nalakrats!

The emphasis on green tea is due to Asians having less PCa. I feel that there is a misleading pro-tea bias in the research. However, pharmaceutical doses seem to be required. Much higher than the physiological doses assumed to be bioactive in an Asian population. I might be wrong, but I don't see green tea as a serious inhibitor of progression. Of course, as part of a polyphenol cocktail, it might be useful.

LEF has a coffee extract:



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Thank you, Patrick. I read a report of a study years ago that found Japanese men (in Japan) who had 10 cups of green tea a day were less likely to get PCa than those who had less. Probably small cups. I miscalculated what it would take in LEF caps, added to the white tea I drink, to make 10 cups. I took 2 at breakfast, 1 at lunch & 2 at dinner. Then you said you took 1 a day, & I stopped wasting all that $. (I didn't have side-effects. I was taking decaf, & switched to lightly caf as you suggested.

I was a Peet's French Roast lover before PCa. I switched to green tea to fight the PCa, but didn't really like it. But I actually do like Teatulia's white tea (just white tea, not a combo). I like both the Peet's & the Teatulia straight (although I also enjoyed occasional lattes & caramel macchiatos pre-dx).

Do you just drink coffee, or do you also use the LEF supplements with large meals? I'm not clear on whether avoiding post-prandial glucose surges is important for us.

I appreciate your efforts & assistance. Now I have French Roast to look forward to!


P.S. When I saw Donald Abrams at UCSF 11 or 12 years ago, he only wanted me to have the amount of caffeine in 3 cups of green tea per day. I do enjoy staying on an even keel, without the jolts & troughs. Maybe I'll mix caf & decaf beans, assuming they don't offer lightly caf.



Avoiding glucose surges is very important IMO. But that can probably be done by avoiding meals where fat is < 30%.



Thanks, Patrick. So shoot for 40% fat at every meal.



Well Patrick I drink about one to one and a half pots a day. This was true before DX, and is true after DX. I ain't giving up my coffee. But hope your presentation is reliable.



Nal, what if anything do you do about green (or white) tea? And what about drinking water? Are you consuming healthy amounts of non-diuretic liquids?



Well, Neil, I drink a lot of water, minimal natural juices as their sugar contents are naturally high. So I sometimes make a 50/50 blend of Unsweetened Almond Milk with Orange Juice. I do drink non-alcoholic beer, once in awhile.

As to Tea, many here do not know I was involved in a lot of the original research on Green and Black Tea, as a research Chemist at Lipton Tea.

My work was with the Polyphenols---the starting base molecule being a Galate.

The problem with tea, is that the important Galates, such as ECG, and EGCG, run molecular weights of from the 600's to the 900's. They are not cold water soluble, and in reality if you look close, hot water extracts---tea ready to drink----they are Opaque--as even with hot water they are partially soluble.

The molecules are too big to pass into the small intestine. The action of HCL Acid may have some action to break up the molecules, in the stomach, but then you destroy the antioxidant activity of the original polyphenols.

So I am not a fan of tea, or tea extracts in pill form. My opinion, based on pure research. Now there may be other things I am not aware of, as my original research, with other PHD Chemists was in the mid-1960's.


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Thank you, Nal! I'd say your scientific explanation pairs well with Patrick's report to make me decide that I'll only be enjoying some Teatulia white tea in the future because I like it, & I'll quit the green tea supplements. Time to enjoy Peet's French Roast again in the AM, & I'll use LEF's green coffee suplements with large meals--at least if you & Patrick think it's important to avoid glucose surges.

I like the almond milk too, & coconut beverage--both things that I like with oatmeal. I just discovered oatmeal milk. It tastes so good that it's great straight!

But wait ... Do you think green (or white) tea may have some health benefits, even if it's not a PCa killer? Or does the size of the galates destroy any potential health benefits from these teas.


Hard to say, but there are over 400 compounds just in the aroma of tea, which means they are in the tea. I would say that there is probably somewhere within those 400 compounds something of worth. My work originally only identified 250 compounds, as the Gas Chromatography equipment was not sensitive enough to separate out, all that was there. About 12-13 years later my work was revised by others, and we now have a good idea of all that is in tea. It couldn't hurt you!



"Italian-style coffee" does mean espresso, it seems. Just 3 shots cuts risk in half.

A 3-shot Americano is all it takes.