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Some Interesting Information - Parkin-mediated Mitophagy
While the clinical trial in the article does not target PD, some interesting facts that may be related to PD. (Inflammation). Will leave to you guys to infer, especially something related Parkin-mediated Mitophagy and how it is affected in PD patients https://www.cell.com/cell-reports-medicine/fulltext
While the clinical trial in the article does not target PD, some interesting facts that may be related to PD. (Inflammation). Will leave to you guys to infer, especially something related Parkin-mediated Mitophagy and how it is affected in PD patients https://www.cell.com/cell-reports-medicine/fulltext
John_morris71
in
Cure Parkinson's
2 years ago
BENZO WITHDRAWAL AND MIRTAZAPINE
I have taken MIRTAZAPINE 15mg for 12 weeks now and some days I feel so lethargic It is an effort to speak! Also very depressed too , obviously this isn’t right ?!?! Also I have been tapering off benzodiazepine at the same time and am now down to dregs of the drug ….. a roller coaster ride, this might
I have taken MIRTAZAPINE 15mg for 12 weeks now and some days I feel so lethargic It is an effort to speak! Also very depressed too , obviously this isn’t right ?!?! Also I have been tapering off benzodiazepine at the same time and am now down to dregs of the drug ….. a roller coaster ride, this might
Loughborough53
in
Mental Health Support
2 years ago
What are your thoughts on breathing techniques vs medication?
Hi Everyone, I am sufferer of asthma, and it has been brought to my attention as to whether the effectiveness of specific breathing techniques vs medication could assist in increasing lung capacity. Breathing techniques: Some sources suggest that breathing exercises can help alleviate asthma symptoms
Hi Everyone, I am sufferer of asthma, and it has been brought to my attention as to whether the effectiveness of specific breathing techniques vs medication could assist in increasing lung capacity. Breathing techniques: Some sources suggest that breathing exercises can help alleviate asthma symptoms
joshuap001
in
Asthma Community Forum
2 years ago
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What are your thoughts on breathing techniques vs medication?
Hi Everyone, I am sufferer of asthma, and it has been brought to my attention as to whether the effectiveness of specific breathing techniques vs medication could assist in increasing lung capacity. Breathing techniques: Some sources suggest that breathing exercises can help alleviate asthma symptoms
Hi Everyone, I am sufferer of asthma, and it has been brought to my attention as to whether the effectiveness of specific breathing techniques vs medication could assist in increasing lung capacity. Breathing techniques: Some sources suggest that breathing exercises can help alleviate asthma symptoms
joshuap001
in
Lung Conditions Community Forum
2 years ago
Nubequa Failing?
I had a PSMA scan in late Nov 2021. A few bone mets and lymph nodes in abdominal area. I had been on just Eligard for 2 years. And before that Lupron and Casodex since 2011 with some vacation time in between and a year, 2017, in a clinical trial using estrodoil applied by applying to shoulders daily.
I had a PSMA scan in late Nov 2021. A few bone mets and lymph nodes in abdominal area. I had been on just Eligard for 2 years. And before that Lupron and Casodex since 2011 with some vacation time in between and a year, 2017, in a clinical trial using estrodoil applied by applying to shoulders daily.
Joey40
in
Advanced Prostate Cancer
2 years ago
Any association between rising PSA and falling T during BCR?
To recap briefly - 65YO, G9 PCa, RP in '16 followed by RT/ADT. BCR in '18...detected in pelvic LNs via PSMA clinical trial. Then RT to that region and 18 months of ADT. No treatment since that ended June '20. Undetectable PSA from Jan '19 thru Oct '21. PSA creeping up from 0.03 in Oct '21 to 0.20 in
To recap briefly - 65YO, G9 PCa, RP in '16 followed by RT/ADT. BCR in '18...detected in pelvic LNs via PSMA clinical trial. Then RT to that region and 18 months of ADT. No treatment since that ended June '20. Undetectable PSA from Jan '19 thru Oct '21. PSA creeping up from 0.03 in Oct '21 to 0.20 in
shueswim
in
Advanced Prostate Cancer
2 years ago
Help
I’m not going to message him but I need reinforcements on why I shouldn’t please. Last Feb. my ex fiancé messaged me that he thought of me sometimes and gets to SA (where I live) for work occasionally. Every year my son gets older is another year without him in my life (we haven’t been together in 23
I’m not going to message him but I need reinforcements on why I shouldn’t please. Last Feb. my ex fiancé messaged me that he thought of me sometimes and gets to SA (where I live) for work occasionally. Every year my son gets older is another year without him in my life (we haven’t been together in 23
ElephantsHear
in
Anxiety and Depression Support
2 years ago
MY JOURNEY: COVID, EVUSHELD, PAXLOVID and CLL
I am sorry this is so long. I really wanted to document and share my journey and remind everyone to be very careful, thoughtful and educated. COVID is no joke! I was diagnosed with Chronic Lymphocytic Leukemia (CLL) in July, 2015. Started a clinical trial of Acalabrutinib (Calquence) in July, 2016 at
I am sorry this is so long. I really wanted to document and share my journey and remind everyone to be very careful, thoughtful and educated. COVID is no joke! I was diagnosed with Chronic Lymphocytic Leukemia (CLL) in July, 2015. Started a clinical trial of Acalabrutinib (Calquence) in July, 2016 at
SandiC
in
CLL Support
2 years ago
Preventing Drug Resistance - Thinking Outside The Box - PRINT Phase 2 Study
One of the biggest challenges of PCa treatment is eventual drug resistance. I've been thinking that maybe Oncologists may have their thinking locked in a box. This is understandable as most take a conservative approach probably, recommending what is "tried and true." So to speak. So I was thinking,
One of the biggest challenges of PCa treatment is eventual drug resistance. I've been thinking that maybe Oncologists may have their thinking locked in a box. This is understandable as most take a conservative approach probably, recommending what is "tried and true." So to speak. So I was thinking,
jazj
in
Advanced Prostate Cancer
2 years ago
Dental care when having clinical depression and anxiety
As someone who suffers from
clinical
depression
I stopped caring about myself and can’t bring myself to do simple tasks like showering or brushing my teeth. Now the negligence has caused me to have very bad teeth and I don’t know what I can do about it.
As someone who suffers from
clinical
depression
I stopped caring about myself and can’t bring myself to do simple tasks like showering or brushing my teeth. Now the negligence has caused me to have very bad teeth and I don’t know what I can do about it.
Imstruggling1
in
Anxiety and Depression Support
2 years ago
How to support someone with depression
Hello. I'm here because I have a boyfriend who has depression and I don't know how to deal or help him or what to do. He started being short and distance with me for like 2 weeks. I got anxious because I felt a shift in the relationship. Last week, he told me that he was struggling for a couple of
Hello. I'm here because I have a boyfriend who has depression and I don't know how to deal or help him or what to do. He started being short and distance with me for like 2 weeks. I got anxious because I felt a shift in the relationship. Last week, he told me that he was struggling for a couple of
KSunshyne
in
Anxiety and Depression Support
2 years ago
Keep spiraling
I seem to be on an endless cycle of depression and anxiety. For many years I was doing well, even thought I had my anxiety and depression beat. However, in the past year I have cycled almost every month for 7 - 8 days. The last two months it has been happening between 14 and 18 days. I believe it
I seem to be on an endless cycle of depression and anxiety. For many years I was doing well, even thought I had my anxiety and depression beat. However, in the past year I have cycled almost every month for 7 - 8 days. The last two months it has been happening between 14 and 18 days. I believe it
lovetodance2018
in
Anxiety and Depression Support
2 years ago
Clinical Trials: costs passed to the patient?
Good morning to all in the best support group team ever! Anybody out there participating in a clinical trial research study and then getting billed for part of the cost of it??? After your insurance coverage has been claimed and paid to your provider, do any of you then get billed for any remaining
Good morning to all in the best support group team ever! Anybody out there participating in a clinical trial research study and then getting billed for part of the cost of it??? After your insurance coverage has been claimed and paid to your provider, do any of you then get billed for any remaining
pollymacchili
in
SHARE Metastatic Breast Cancer
2 years ago
Depression and loved ones
So I've been in a long distance relationship for almost a year now with someone who has severe depression. I also have depression but, I am able to go about my day and push through. Unfortunately that's not the case for him and he pulls away from me often. I am always torn between giving him space but
So I've been in a long distance relationship for almost a year now with someone who has severe depression. I also have depression but, I am able to go about my day and push through. Unfortunately that's not the case for him and he pulls away from me often. I am always torn between giving him space but
Felix0225
in
Anxiety and Depression Support
2 years ago
Is a Clinical Trial Right for You?
Hi, Have you ever considered participating in a clinical trial? Join CLL Society on Monday, May 16 at 11am PT / 2pm ET for our webinar: Is a Clinical Trial Right for You? Dr. Adrian Wiestner from the NIH and RN Kennard from U PENN will detail the benefits and risks of participating in a clinical trial
Hi, Have you ever considered participating in a clinical trial? Join CLL Society on Monday, May 16 at 11am PT / 2pm ET for our webinar: Is a Clinical Trial Right for You? Dr. Adrian Wiestner from the NIH and RN Kennard from U PENN will detail the benefits and risks of participating in a clinical trial
bkoffman
CLL CURE Hero
in
CLL Support
2 years ago
Mixed news for flavonoids.
New meta-analysis below [1]. The flavonoid family (Anthocyanidins, Anthoxanthins, Flavanones, Flavanonols, Flavans, & Isoflavonoids) include members that have hormone-like properties. "This meta-analysis was aimed to explore the association between flavonoids intake and {hormone-related cancer} HRC
New meta-analysis below [1]. The flavonoid family (Anthocyanidins, Anthoxanthins, Flavanones, Flavanonols, Flavans, & Isoflavonoids) include members that have hormone-like properties. "This meta-analysis was aimed to explore the association between flavonoids intake and {hormone-related cancer} HRC
pjoshea13
in
Advanced Prostate Cancer
2 years ago
Why I Choose an Unproven Treatment
It is a rainy stormy day in Perth, Western Australia, called the "most remote city in the world". I arrived here yesterday with more than 30 hours of travel from Oregon USA. Tomorrow I will get my first infusion of Lutetium 177-PSMA (mAb)-J591. An experimental and unproven new form of radioactive ligand
It is a rainy stormy day in Perth, Western Australia, called the "most remote city in the world". I arrived here yesterday with more than 30 hours of travel from Oregon USA. Tomorrow I will get my first infusion of Lutetium 177-PSMA (mAb)-J591. An experimental and unproven new form of radioactive ligand
MateoBeach
in
Fight Prostate Cancer
2 years ago
Why I Choose an Unproven Treatment
It is a rainy stormy day in Perth, Western Australia, called the "most remote city in the world". I arrived here yesterday with more than 30 hours of travel from Oregon USA. Tomorrow I will get my first infusion of Lutetium 177-PSMA (mAb)-J591. An experimental and unproven new form of radioactive ligand
It is a rainy stormy day in Perth, Western Australia, called the "most remote city in the world". I arrived here yesterday with more than 30 hours of travel from Oregon USA. Tomorrow I will get my first infusion of Lutetium 177-PSMA (mAb)-J591. An experimental and unproven new form of radioactive ligand
MateoBeach
in
Advanced Prostate Cancer
2 years ago
We have reached castrate resistance...what to do next?
I have been following this forum for a couple of years now, and have learned so much from all of you. But this is my first time to post...I knew this time would eventually come, but somehow it still caught me off guard. Dad is now 75; he was diagnosed with stage IV metastatic prostate cancer December
I have been following this forum for a couple of years now, and have learned so much from all of you. But this is my first time to post...I knew this time would eventually come, but somehow it still caught me off guard. Dad is now 75; he was diagnosed with stage IV metastatic prostate cancer December
Bmvg02
in
Advanced Prostate Cancer
2 years ago
Rank Neutraceuticals / Off-Label Drugs By Most Likely Most Beneficial
I'm curious about the opinions of members here on how they would currently rank Neutraceutical and off-label use drugs in order of highest benefit potential (most confirming clinical trial evidence combined with actual therapeutic or synergistic therapeutic effect) in slowing/stopping PCa progression
I'm curious about the opinions of members here on how they would currently rank Neutraceutical and off-label use drugs in order of highest benefit potential (most confirming clinical trial evidence combined with actual therapeutic or synergistic therapeutic effect) in slowing/stopping PCa progression
jazj
in
Advanced Prostate Cancer
2 years ago
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