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PROTAC: An Effective Targeted Protein Degradation Strategy for Cancer Therapy
In 2015, the Bradner group has developed the first CRBN-based PROTAC, with the structure of
pomalidomide
capturing CRBN and BRDs inhibitor JQ1 as POI ligand.
In 2015, the Bradner group has developed the first CRBN-based PROTAC, with the structure of
pomalidomide
capturing CRBN and BRDs inhibitor JQ1 as POI ligand.
Scout4answers
in
Advanced Prostate Cancer
2 years ago
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