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[EAU-2020] Enzyme inhibition for overcoming CRPC.
"'Significant circulating concentrations of DHEAS still exist in patients with prostate cancer being treated with
abiraterone
,” Gao continued.
"'Significant circulating concentrations of DHEAS still exist in patients with prostate cancer being treated with
abiraterone
,” Gao continued.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
UK - Abiraterone too expensive for non-CRPC mPCa?
'“There are concerns that the trials may overestimate the effectiveness of
abiraterone
,” the agency wrote in the final appraisal document.' https://www.onclive.com/view/nice-passes-on-
abiraterone
-for-newly-diagnosed-high-risk-metastatic-hormone-sensitive-prostate -Patrick
'“There are concerns that the trials may overestimate the effectiveness of
abiraterone
,” the agency wrote in the final appraisal document.' https://www.onclive.com/view/nice-passes-on-
abiraterone
-for-newly-diagnosed-high-risk-metastatic-hormone-sensitive-prostate -Patrick
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Abiraterone failing...Xtandi next best step?
Started on lupron/
abiraterone
/prednisone and Xgeva infusions every 3 months. PSA lowered to 63.6 then 38.9 to 1.2 in December. PSA was 1.6 in January, 2.4 in February and 14.1 in May. Doctor wants to change from
abiraterone
to Xtandi. Has anyone had success with Xtandi?
Started on lupron/
abiraterone
/prednisone and Xgeva infusions every 3 months. PSA lowered to 63.6 then 38.9 to 1.2 in December. PSA was 1.6 in January, 2.4 in February and 14.1 in May. Doctor wants to change from
abiraterone
to Xtandi. Has anyone had success with Xtandi?
Yadifan
in
Advanced Prostate Cancer
4 years ago
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Treatment after chemo - PARP inhibitor or immunotherapy trial?
I've taken Xtandi and
Abiraterone
. I had Provenge in 2016. I have discussed the next step with my MO at MD Anderson. One option is a PARP inhibitor.
I've taken Xtandi and
Abiraterone
. I had Provenge in 2016. I have discussed the next step with my MO at MD Anderson. One option is a PARP inhibitor.
WhiteStrat
in
Advanced Prostate Cancer
4 years ago
PARP Inhibitors for Metastatic Castration-Resistant Prostate CancerInterview with Oliver Sartor MD
All the patients, in essence, were pretreated with
abiraterone
and enzalutamide, and they may or may not have been pretreated for docetaxel. The patients included not only BRCA1 and BRCA2, but in a “cohort A” also included patients with a deleterious mutation in ATM.
All the patients, in essence, were pretreated with
abiraterone
and enzalutamide, and they may or may not have been pretreated for docetaxel. The patients included not only BRCA1 and BRCA2, but in a “cohort A” also included patients with a deleterious mutation in ATM.
Balsam01
in
Advanced Prostate Cancer
4 years ago
A new chapter
Began ADT &
abiraterone
in Jan. '19, followed by RT on LNs. Continued ADT/
abiraterone
combo through yesterday. PSA has been undetectable since ADT began. My plan of attack was formulated 18 months ago by my local RO and Dr. Zietman at MGH with the intent of being curative.
Began ADT &
abiraterone
in Jan. '19, followed by RT on LNs. Continued ADT/
abiraterone
combo through yesterday. PSA has been undetectable since ADT began. My plan of attack was formulated 18 months ago by my local RO and Dr. Zietman at MGH with the intent of being curative.
shueswim
in
Advanced Prostate Cancer
4 years ago
Dr. Oliver Sartor on Rucaparib & Olaparib.
All the patients, in essence, were pretreated with
abiraterone
and enzalutamide, and they may or may not have been pretreated for docetaxel. The patients included not only BRCA1 and BRCA2, but in a “cohort A” also included patients with a deleterious mutation in ATM.
All the patients, in essence, were pretreated with
abiraterone
and enzalutamide, and they may or may not have been pretreated for docetaxel. The patients included not only BRCA1 and BRCA2, but in a “cohort A” also included patients with a deleterious mutation in ATM.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
To state the obvious: early use of Zytiga or Xtandi extends survival in APC
Here's what he replied: "Although long term androgen deprivation therapy may be
associated
with the development of treatment-emergent small cell neuroendocrine prostate cancer (t-SCNC) in a minority of patients, multiple studies have confirmed the long-term benefit of
abiraterone
and enzalutamide
Here's what he replied: "Although long term androgen deprivation therapy may be
associated
with the development of treatment-emergent small cell neuroendocrine prostate cancer (t-SCNC) in a minority of patients, multiple studies have confirmed the long-term benefit of
abiraterone
and enzalutamide
Tall_Allen
in
Advanced Prostate Cancer
4 years ago
Happy Fourth of July y'all
Did my liver Panel so I could renew
Abiraterone
Rx. Sported my latest mask and my Virtual 5k run tee for Tehachapi Parks and Recs. Signed up with a Team to do 76 miles to support Men with PCa this month They gave me "Stat" status and I had the results before I got home!
Did my liver Panel so I could renew
Abiraterone
Rx. Sported my latest mask and my Virtual 5k run tee for Tehachapi Parks and Recs. Signed up with a Team to do 76 miles to support Men with PCa this month They gave me "Stat" status and I had the results before I got home!
dockam
in
Advanced Prostate Cancer
4 years ago
PSA stable, but not at zero🤔
Hey gang, latest PSA at 4.3, up from 4.1 and 4.2 previously On
Abiraterone
since January 2020 and was hoping it would approach nil. T under 3, on Lupron, Metformin, and Lipitor. Life with #stageivpca So, still in the game so far💙 Fight on Brothers Randy
Hey gang, latest PSA at 4.3, up from 4.1 and 4.2 previously On
Abiraterone
since January 2020 and was hoping it would approach nil. T under 3, on Lupron, Metformin, and Lipitor. Life with #stageivpca So, still in the game so far💙 Fight on Brothers Randy
dockam
in
Advanced Prostate Cancer
4 years ago
Comparing the Clinical Efficacy and Safety of Abiraterone and Enzalutamide in Metastatic CRPC.
Keywords: Metastatic castration-resistant prostate cancer;
abiraterone
; enzalutamide; meta-analysis.
Keywords: Metastatic castration-resistant prostate cancer;
abiraterone
; enzalutamide; meta-analysis.
pjoshea13
in
Advanced Prostate Cancer
4 years ago
Comparing Benefit and Costs for Abiraterone and Enzalutamide in Hormone-Sensitive and Castrate-Resistant Metastatic Prostate Cancer
From the article: [i]"Ultimately,
abiraterone
and enzalutamide provide clinical benefit across all approved settings and have higher cost when used earlier in the course of metastatic prostate cancer.
From the article: [i]"Ultimately,
abiraterone
and enzalutamide provide clinical benefit across all approved settings and have higher cost when used earlier in the course of metastatic prostate cancer.
cujoe
in
Fight Prostate Cancer
4 years ago
Ipatasertib - Phase III study with Abiraterone,
In the study, patients were randomized to 1 of 3 arms: ipatasertib (400 mg) plus
abiraterone
(1000 mg) and prednisone/prednisolone (n = 84); ipatasertib (200 mg) plus
abiraterone
(1000 mg) and prednisone/prednisolone (n = 87); or placebo plus
abiraterone
(1000 mg) and prednisone/prednisolone (n = 82)
In the study, patients were randomized to 1 of 3 arms: ipatasertib (400 mg) plus
abiraterone
(1000 mg) and prednisone/prednisolone (n = 84); ipatasertib (200 mg) plus
abiraterone
(1000 mg) and prednisone/prednisolone (n = 87); or placebo plus
abiraterone
(1000 mg) and prednisone/prednisolone (n = 82)
pjoshea13
in
Advanced Prostate Cancer
4 years ago
New Abiraterone (Zytiga) formulation
A promising new oil-base oral formulation of
Abiraterone
in the works! Claims to improve the drug's "effectiveness by 40 per cent". For me, the mention of side effect improvement of joint swelling and diarrhea, is great. https://www.eurekalert.org/pub_releases/2020-06/uosa-bdt061920.php
A promising new oil-base oral formulation of
Abiraterone
in the works! Claims to improve the drug's "effectiveness by 40 per cent". For me, the mention of side effect improvement of joint swelling and diarrhea, is great. https://www.eurekalert.org/pub_releases/2020-06/uosa-bdt061920.php
DarkEnergy
in
Advanced Prostate Cancer
4 years ago
Additional confirmation of possible COVID-19 benefits for those on abiraterone - FDA-approved drugs , , , as potential COVID-19 treatments
Additional confirmation of possible COVID-19 benefits for those on
abiraterone
.
Additional confirmation of possible COVID-19 benefits for those on
abiraterone
.
cujoe
in
Fight Prostate Cancer
4 years ago
PSA rising
OC2
is suggesting
Chemo
as his preferred line to treatment now to manage this or we could try
for
45-60
days and see how that goes.
OC2
is suggesting
Chemo
as his preferred line to treatment now to manage this or we could try
for
45-60
days and see how that goes.
seeker47
in
Advanced Prostate Cancer
4 years ago
Xtandi to Zytiga
I started Zytiga (
Abiraterone
) 28 days ago and just received my first lab...PSA jumped to 14.16. That put a scare in me. Can anyone relate to this large jump or does that say that Zytiga is not going to work for me and that I’d better get on to another treatment? Thank you for your time!
I started Zytiga (
Abiraterone
) 28 days ago and just received my first lab...PSA jumped to 14.16. That put a scare in me. Can anyone relate to this large jump or does that say that Zytiga is not going to work for me and that I’d better get on to another treatment? Thank you for your time!
docbulldog
in
Advanced Prostate Cancer
4 years ago
Psa doubling time
My dad diagnosed advanced metastatic prostate cancer 3.2 years back with several bony Mets no pain walks 15000 steps everyday he's been on pamorelin hormone injection +
abiraterone
( type of zytiga) + 5 mg Prednisone for last three years but I am concerned about his rising psa last from this last
My dad diagnosed advanced metastatic prostate cancer 3.2 years back with several bony Mets no pain walks 15000 steps everyday he's been on pamorelin hormone injection +
abiraterone
( type of zytiga) + 5 mg Prednisone for last three years but I am concerned about his rising psa last from this last
Nirman
in
Advanced Prostate Cancer
4 years ago
Is radiation still a good idea? Can APC be cured (until last week I always heard no)?
CLINICAL HISTORY: 55 years man with biopsy-proven prostate cancer on 10/20/2019; Gleason score = 4+5 Management = ADT and
abiraterone
Most recent PSA = less than 0.1 ng/ml; PSA date = 5/29/2020 TECHNIQUE: Multiplanar T1, T2, and diffusion weighted MR images were obtained through the pelvis on a
CLINICAL HISTORY: 55 years man with biopsy-proven prostate cancer on 10/20/2019; Gleason score = 4+5 Management = ADT and
abiraterone
Most recent PSA = less than 0.1 ng/ml; PSA date = 5/29/2020 TECHNIQUE: Multiplanar T1, T2, and diffusion weighted MR images were obtained through the pelvis on a
barrybayarea
in
Advanced Prostate Cancer
4 years ago
PSA Drop After ADT Holiday
After an 8 month holiday from Lupron/
Abiraterone
my PSA rose to 0.55 from a nadir at 0.01. After resuming ADT for a bit more than a month my PSA has dropped to 0.02. I didn’t expect such a sharp reduction. Is this to be expected, assuming I remained hormone sensitive?
After an 8 month holiday from Lupron/
Abiraterone
my PSA rose to 0.55 from a nadir at 0.01. After resuming ADT for a bit more than a month my PSA has dropped to 0.02. I didn’t expect such a sharp reduction. Is this to be expected, assuming I remained hormone sensitive?
6357axbz
in
Advanced Prostate Cancer
4 years ago
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