Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction (Mouse study)

[ElliotGreen]

Sato, Shigeto, et al. "Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice." Scientific reports 8.1 (2018): 2813.

FULL ARTICLE FREE:

nature.com/articles/s41598-...

[Xenos]

Very good find, thank you. My fasting may not be pointless after all .

[sharoncrayn]

So....synuclein is predominantly degraded by autophagy, but also by the proteasome. But a few of us also know autophagy prevents (supposedly) tumor initiation and allows cells to survive debilitating stress i.e. to somehow limit cell death. And the brain is made up of a whole lot of cells, like 85 billion or so, so it is obviously relevant in PD to look at this presentation somewhat skeptically.

Do I see a conundrum here? Really Sharon? But these were rats, so I guess it might not transfer to humans, but it will be avidly read by the rat population and discussed on their lab forums.

[Xenos in reply to sharoncrayn]

...unless rats successfully experiment on humans.

[Kevin51]

thanks for an interesting ref!

K