um_PEA?

[Jimmary]

Would love to hear comments on this... new to me.

news-medical.net/news/20170...

[Serenity_finaly-1]

????????????????????? what ??????? um_PEA ???????? sounds like a practical joke. DR, DR, what is um pea about ??????

[Hidden]

Ummm! I will consider putting um-PEA adjuvant therapy in my future study. Presently I am testing the thiamine (vitB1) treatment and also daily high dose of magnesium malate. In the last couple days I have noticed a reduction in tremors and surprising an improvement in my vision.

[glenandgerry in reply to Hidden]

That's great news Hidden

[glenandgerry in reply to glenandgerry]

What other supplements are you taking and what quantity of B1 and Magnesium Malate? My husband just started taking Subutimine (B1) but stopped taking Malate, so maybe we should reintroduce that again.

[Hidden in reply to glenandgerry]

Emergen-C only occasionally.

750mg B1

Mag bottle ingredients say:

425mg mag as mag malate

2.5 grams malic acid as mag malate and malic acid

Quotes from reference material:

Doctor Costantini remembers that helping his very first patient, afflicted by an acute ulcerative, set him on the path towards countering Parkinson’s disease. He advised her to inject herself with two mg of Thiamine per week. “In the first 15 days of the therapy the patient was relieved of exhaustion, irritability, pain in her feet and calves”– says doctor Costantini- “Why is this? Because there is no medicine or drug that is able to affect all of the organs, whereas all of the organs function thanks to Thiamine.An important detail”,adds doctor Costantini, “the Thiamine therapy brings no collateral damage with time”.

What is the best way to integrate Vitamin B1?

Biovea B1 in tablets of 500 mgs (no prescription required – “over the counter”)

Normally the medication regimen consists of one tablet per day for the first month…..

As a general rule the initial minimum dose administered for the cure of diverse neurodegenerative disorders consists of two vials of 100 mg per week or 4 grams per day to be taken by mouth.

ultimaedizione.eu/costantin...

“In 2011 our team was working with dosages based on the body weight: 60 Kg corresponded to 600mg of vitamin B1, to be taken orally and yielding marvelous results: the elimination of exhaustion and all the symptoms that accompany it”.

[glenandgerry in reply to Hidden]

I have previously read about Dr Costantini and have seen the before and after patient videos. I understood the Vit B1 was best taken via injection but the next best way of ingestion was Sulbutiamine (synthetic Vit B1), but if the Biovea High Potency Vit B1 works for you, then I will definitely give this a try for my husband who, like you, is tremor dominant.....it's a good price too! Thanks Roy

[Hidden in reply to glenandgerry]

Biovea B1 ? That was brand mentioned in the reference. Not that I recommend or use.

[Hidden in reply to glenandgerry]

raypeatforum.com/community/...

Since most people would not have easy access to thiamine injections, an alternative is oral allithiamine. It achieves the same concentrations (and cellular activity) through oral administration as IV or IM thiamine Hcl. So, oral allithiamine at a dose of just 100mg twice a week should be able to replicate the results of this study.

ncbi.nlm.nih.gov/pubmed/978282

"...Oral administration of lipid-soluble allithiamines [thiamine propyl disulfide (TPD) and thiamine tetrahydrofurfuryl disulfide (TTHF)] rapidly increased thiamine activity in whole blood, red blood cells, cerebrospinal fluid, and urine in normal and thiamine-deficient subjects. These thiamine congeners also restored red blood cell transketolase to normal in alcoholics with thiamine deficiency. Such repletion equaled that produced by parenteral, water-soluble thiamine hydrochloride (THCl) or thiamine pyrophosphate (TPP). Oral administration of water-soluble thiamines (THCl, TPP) neither elevated thiamine activity in biological fluids nor restored transketolase activity to normal in alcoholics with thiamine deficiency presumably due to their rate-limited intestinal transport. Oral administration of TPD eliminated lateral rectus palsy in patients with Wernicke's encephalopathy. Orally administered allithiamine vitamers are therefore recommended for prophylaxis and treatment of thiamine deficits because while having essentially the same biological properties as parenterally administered water-soluble thiamines they have not produced any untoward effects after long-term administration and are far more efficiently utilized."

Thiamine Mononitrate

livestrong.com/article/3132...

Thiamine mononitrate is synthetic and has the potential to illicit mild to severe allergic reactions.

The nitrates present in thiamine mononitrate may accumulate in the kidneys and induce kidney stones or cellular death.

[rebtar in reply to Hidden]

What does the magnesium malate do?Does the VC and malate combine in some way with b1 or just something you take in addition?

[Hidden in reply to rebtar]

take in addition

search info on google

Magnesium malate: pain relief

Malic acid, bound to magnesium to form magnesium malate, is an intermediary in the Krebs cycle and involved in energy metabolism. Dr Gee Abraham first hypothesised that fibromyalgia syndrome may be due to a defect in cellular metabolism characterised by low ATP production (leading to the characteristic symptoms of fatigue) and a build up of organic acids (explaining the diffuse muscle pain). Supplementation with magnesium malate – to provide magnesium for acetyl-CoA synthesis and malic acid for malate dehydrogenase activity – may be able to improve energy metabolism and relieve fibromyalgia, he theorized.

In an open label study to test this hypothesis Abraham et al (1992) reported that oral treatment with magnesium malate (300-600 mg magnesium and 1200-2400 mg malate daily) for 8 weeks improved fibromyalgia pain (16). A follow up placebo controlled trial however failed to demonstrate benefit but this may be due to a shorter treatment duration (4 weeks) and lower dose (300 mg magnesium and 1200 mg malate daily)

timeforwellness.org/blog-vi...

[hanifab23 in reply to Hidden]

please tell me which brand and where to purchase from

[Hidden in reply to hanifab23]

thiamine (vitB1): Spring Valley brand, Wal-mart

Magnesium malate: Source Naturals, amazon/Source Naturals Magnesium Malate 1250mg, Supports Muscles and Energy Production,360 Tablets

amazon.com/gp/product/B000G...

carb/levodopa: 1x50/200 at 8 am; 2x50/200 at 5 pm

[Catlou in reply to Hidden]

whose brands?

[Hidden in reply to Catlou]

Ecological Formulas Allithiamine Vitamin B1 Capsule, 50 mg

Magnesium malate: Source Naturals, amazon/Source Naturals Magnesium Malate 1250mg

[bone60]

Thiamine may be contraindicated with cancer.

[Hidden in reply to bone60]

Thiamine is added to all cereal in Canada

Here is what the post is about:

Palmitoylethanolamide, an endogenous fatty acid amide signalling molecule well-known for its ability to promote the resolution of neuroinflammation and exert neuroprotection, has shown potential therapeutic action in such animal models. In our research, we show that ultra-micronized palmitoylethanolamide (um-PEA), slows down disease progression and disability when used as add-on therapy in advanced PD patients.

[Jimmary]

Thanks for getting back on the subject. Seemms like it would benefit all PD foks. I wonder if anyone is trying it and if a prescription is needed for it.

[aspergerian in reply to Jimmary]

I saw it on web, eg, Amazon.