Hello. My mom taking Lynparza and ca125 slowly rising. From 138 to 150. BRCA2 positive. What can be reason? Lynparza not working anymore?

[Sanssa]

Lynparza

[Esmerelda101]

Hi There, I’m also in this position, CA rising and have been taking Lynparza for 4 months, I’m BRCA1. Had a scan which showed NED but my doc thinks it’s just a matter of time before the cancer becomes visible. She is not sure if the Lynparza may be slowing the growth and how long it will take to become a problem. It’s like a serious game of “where’s Wally”! Most importantly if your Mum still feels well then it’s Just an indicator that needs to be monitored, I will have another scan in a few months. Keep me posted, would be really interested in her doctors opinion. I think they are still in uncharted territory when CA levels rIse on knowing if the meds are still being effective but not 100%. Take Care and hoping for the best outcome for you both. X

[Sanssa in reply to Esmerelda101]

Thanks a lot. Doctor visit on Tuesday.

[sticky3006]

Hello Sanssa,

how long has your mum been on Olaparib/Lynparza? Does she feel well and does she have any symptoms? Hopefully if she has a CT scan it may not show anything and if there is some disease progression the drug will hopefully be slowing it down. Good luck when you speak to the doctor, sticky3006 xx

[Sanssa in reply to sticky3006]

Hi.

Thank You so much.

She is on Lynparza 5 months. First weeks she felt terrible, was vomiting all the time and loss of appetite. And iron level was very low. Her ca125 results gone down, but last 2 months slowly start rising. Now she feeling very well. And im very worry that doc will say, that Lynparza not working anymore.

[sticky3006 in reply to Sanssa]

Hello Sanssa, Hopefully they'll do a scan and recheck ca125. Did her ca125 go back down to normal levels in the first few months? Did she start Lynparza after maintenance chemo? thanks

[Sanssa in reply to sticky3006]

No, ca125 drop from 288 to ~188, after first month. Then every month drop about 20, then rise +8 and + 13

Yes, she start after maintenance chemo. During chemo, ca125 was rising, dropping and again rising. But chemo was without platin, cuz was allergy from platin.

Are You on Lynparza as well?

[sticky3006 in reply to Sanssa]

Hello, yes I am but only since April. My ca125 has been between 10 and 15. It went up last month as I had a chest infection but has then come back down to 12. I'm BRCA2 also, thanks x

[Sanssa in reply to sticky3006]

My mom has an UTI, but i not think so, that thats why ca rised...

[mupash]

HI- WONDERING WHAT STAGE YOUR MOM WAS WHEN DIAGNOSED?

I HOPE LYNPARZA KICKS IN SOON-

LEE

[Sanssa in reply to mupash]

3c, In 2015