I take Ezomeprazole for the reflux and am having problems with reflux now. It used to be only at night but now it is during the day as well. I have problems with the pylorus sphincter being too narrow and recently had a dilatation and botox in that area. I frequently have this burning acid coming up into the back of my throat and it is disturbing my sleep at night and my quality of life during the day. I also take 30mg Codeine for my loose stools, 10mg Metoclopremide 3 times a day for the nausea but it doesn't help much. Have tried the Gaviscon but the effect only lasts an hour at the most and then the bad yellow acid coming up to the back of my throat is back. I have tried Lanzoprazole and Omeprazole in the past and the same things happened with that. Why isn't the Ezomeprazole working now? I eat small meals twice a day and the pain at the bottom of my stomach hurts in my chest nearly all the time and i have to take Paracetamol at it's worse to help.