In looking into last week's press release in ScienceDaily about the joint effort by MIT and the Broad Institute on the re-purposing on non-oncology drugs for cancer treatment, I found this amazing interactive webpage that allows you to select various criteria (method of action {MOA}, protein target {Target}, Disease Area, Clinical Phase, and/or Vendor) for an instantaneous readout for individual or combination inputs. For example, you can pick a MOA, such as Androgen Receptor Antagonist (for which there are seven drugs in the dataset), and the results will list all drugs for that MOA and clicking on each drug brings a pop-up profile of the drug with detailed info such as the FDA Orange Book info on dates of approval & patent expiration, molecular diagram, indications for use, etc.
Using this and specific genetic testing results, one could produce the sort of table of drugs-to-targets that firms like Foundation One prepare for their customers. Not sure exactly how I would use it yet, but it is a good example of how the science really is progressing. I also find it reassuring that this is apparently being maintained as a free, open-source resource with access unrestricted to the general public. If knowledge is power, the only way for patients to get that knowledge is with open access to the information that serves as the foundation for the understanding that leads to it.
Here is the link to Broad Institute press release that was the source for the last weeks ScienceDaily article:
Broad Institute News / 01.20.20: Dozens of non-oncology drugs can kill cancer cells
broadinstitute.org/news/doz...
And the link to the CLUE REPURPOSING interactive dataset webpage
Go crazy with it & Be Well - K9
