Natural history of motor symptoms in Parkinson’s disease and the long-duration response to levodopa

[Farooqji]

The natural pattern of progression of Parkinson’s disease is largely unknown because patients are conventionally followed on treatment. As Parkinson’s disease progresses, the true magnitude of the long-duration response to levodopa remains unknown, because it can only be estimated indirectly in treated patients. The study was aimed to describe the natural course of motor symptoms by assessing the natural OFF in consecutive Parkinson’s disease patients never exposed to treatment (drug-naïve), and to investigate the effects of daily levodopa on the progression of motor disability in the OFF medication state over a 2-year period

academic.oup.com/brain/arti...

[rescuema]

The below post today is also relevant.

healthunlocked.com/parkinso...