Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits

[Farooqji]

frontiersin.org/articles/10...

[GymBag]

Um , I appreciate that you bring a lot of information, BUT

I really don't understand a lot of it. If you understand it which I believe you probably do, would you mind giving us a brief synopsis of what it is that we should be looking for in these leads that has you excited . Remember some of us were in formal education 40 years ago and I can not remember seeing " Mesocorticolimbic " in my reading material. The term Laymans language comes to mind.

Thanks

[Farooqji in reply to GymBag]

I will translate it into simple and self explanatory words when I will be free. Currently I am extremely busy at my workplace

[pvw2 in reply to Farooqji]

Especially if it implies any actions we can do now.

[Not4evr]

The issue is how does one obtain ibogaine, visit Mexico or South America ?

[Trixiedee in reply to Not4evr]

Ibogaine comes from Gabon in Africa. You can buy it online. If you search for older ibogaine threads then you’ll find a link. I considered it but it’s really expensive.

[Not4evr in reply to Trixiedee]

I tried searching for the link but my spasms did not give me much time to look for it. Could you please send me the link.

[silvestrov]

This study is about ibogaine's inhibition of consumed alcohol and other drugs (addictive effects), but not Parkinson's disease.

"Ibogaine is the main indole alkaloid isolated from the root bark of the African shrub Tabernanthe iboga (Lavaud and Massiot, 2017). Traditionally used in African religious ceremonies as a psychedelic, ibogaine became a subject of interest to the scientific community due to its reported ability to reduce craving and self-administration of several drugs of abuse in humans (Brown, 2013)."

"A few years ago, a novel hypothesis linking ibogaine’s attenuation of alcohol self-administration in rodents to its ability to modulate the expression of Glial Cell Derived Neurotrophic Factor (GDNF) in the brain was proposed."

There is a anti-alcohol flavonoid, dihydromyricetin, which has been tested in a PD model.

First, Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication ncbi.nlm.nih.gov/pmc/articl...

Secondly, Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity

ncbi.nlm.nih.gov/pmc/articl...

Ibogaine is years away from being used as a PD therapeutic agent due to its hallucinogenic properties but dihydromyricetin is much closer with at least 1 PD study. Dihydromyricetin supplements are safe and available online:

duckduckgo.com/?q=dihydromy...

[Trixiedee in reply to silvestrov]

There are accounts of people with Parkinson’s microdosing ibogaine and getting good results.