Can someone please explain why I sometimes get zero "ON" time relief from my 250mg c/l tabs. Yesterday only 1 out of 5 doses gave me 90 minutes of relief and the other 4 doses just gave me severe dyskinesia for 2 hours per dose!
I am slowly trying to replace all c/l with Mucuna, any successful strategy? or plans? and will doing this drastically cut down on the Dyskinesia symptoms?
Suffer For Jesus Christ, all Glory to the Lord!
God Speed!
For some reason immediate release C/L gets prescribed by default instead of a time release version. The immediate release version tends to cause dyskinesia due to overload of levodopa. The time release versions are much less prone to that problem. They are designated Sinemet CR or carbidopa levodopa ER. Also Rytary is a time release version.
Hi - I have been taking a half 25/250 C/L tablet plus 1 Source Naturals Mucuna Dopa usually 4 times a day. Sometimes it takes 2 hours to kick in but I have also experienced effectiveness after 30 minutes ( not often enough). Sometimes I take either one or the other and not both and it seems to work then too. When my meds are working, I am totally different. No problems with anything while I am inside the house. My on time can be 3 hours or less. Once they are not working I have to sit down quite a while. Then I have to wait for my next dose to work. In the meantime if I have to do anything I have to get someone to help me or I use a walker to help with balance. I can go up and down stairs even when my medication is not working but once I get back to flat ground I have trouble walking straight ahead. Sometimes my feet cramp up making it difficult to walk. I tried to walk all the time around my house with a walker if necessary. I am grateful for my strong legs. I feel like I am rambling, my apologies.
hello there, your not rambling at all, I appreciate the information, feel free to talk about anyhting you would like,,,we all need each other to lean on at times for support, or just to say hi,,,, God Bless You and God Speed. 8)
Mark
Has to be food intake...also sounds like you might have diphasic dyskinesia
have been watching my protien in take for a while now, eat very little fish, pork, red meat and cheeses, taking in umder under 25g per day, thank you for the advice I will speak to doc about the diphasic GOD BLESS YOU!
Mark, are you suffering from the constipation? C/) Dopa is absorbed only in a particular part of the intestines. Constipation affects the speed of absorption. Also what you eat and when can affect your response to the medication. You might be taking too much ld . I tried Zandopa and never could get good results.
Yes Indeed !!! this is what I found out a few weeks ago that the levadopa is absorbed in the small intestine, and depending on the severity of the constipation it could block a high % of the c/l from entering the blood stream.
I had been constipated having only 2 bowel movements in 2 weeks, so last Friday i took to the Prune juice, sipping 8 ounce glass every few hours for the whole day, and by the blessings of the holy spirit I exploded, everything coming out of me except the kitchen sink! and it kept coming out, I lived on the throne all day Friday, then yestserday, for the first time ever, I went through my 5 daily doses of 250mg c/l with no down time!! with each dose averaging 20 minites to kick in. All glory goes to Jesus Christ as I was gifted a day to remember, 16 hours of straight "ON" time with no "OFF" Times, DID YOU HEAR ME! I SAID NO OFF TIMES!! Praise the Lord! and im off to the same type of start today!!!! I do know there will still be days that are difficult not all days will be like this one that was filled with Gods BLessings!!!!
Thank you and bless you all who have given priceless advise and information on this vile murderer of a desiese.
ALL GLORY GOES TO JESUS CHRIST OUR LORD AND SAVIOR!!
PS. Going to start doing a Prune juice cleanse once a week and add a full glass each day to my diet and also a daily glass of vegtable juice both have only 1-2g of protien per serving. I also have to be very strict with my protien intake, my system is very sensitive to protein, this has been a difficult process but has to be done.
Try having a big green salad with as many things as possible eg cabbage, lettuce, spinach etc with lunch and dinner. that in my experience causes many of these explosions and a clearing out of the system!
Yes LA...been eating salads with a variety of components...thank you so much though for the advice... God BLess..
God’s pharmacy I’d say!
help , fatigue, shortness of breath
Akathisia or dyskinesia?
Lets talk about levadopa. While it is reputed to be the most valuable medication in PD it can cause dyskinesia which alarms me.
Has anyone been able to reduce their C/L dose once they started on High Dose Therapy B-1? If so, how and why did you decide to reduce C/L? Any guidance on how to switch from IR C/L to CR C/L during the day?
