a drug called clioquinol, currently used as an anti-parasitic drug, overcomes the effect of the mutant LRRK2 and restores the acidity of the lysosome and clears out the protein aggregates.
Clioquinol - New method developed to targ... - Cure Parkinson's
Clioquinol - New method developed to target cause of Parkinson's
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Farooqji
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Only works for the R1441C mutation, not the more common G2019S mutation. Also was only tested in cell culture, not a whole animal. So this is a long way from an actual treatment:
"Treatment of primary cortical neuronal cultures with clioquinol increased LC3-IIflux in LRRK2-R1441C cultures "
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